MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 584823 | Name: NLP 1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NLP 1 is a DNA intercalating hypoxic cell radiosensitizer and cytotoxin.

Chemical Structure

NLP 1
CAS#121064-77-5

Theoretical Analysis

MedKoo Cat#: 584823

Name: NLP 1

CAS#: 121064-77-5

Chemical Formula: C19H17BrN4O2

Exact Mass: 412.0535

Molecular Weight: 413.28

Elemental Analysis: C, 55.22; H, 4.15; Br, 19.33; N, 13.56; O, 7.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
NLP 1; NLP-1; NLP1; 2-Nlp-3
IUPAC/Chemical Name
Phenanthridinium, 5-(3-(2-nitro-1H-imidazol-1-yl)propyl)-, bromide
InChi Key
GYVSOOVXJXMCIJ-UHFFFAOYSA-M
InChi Code
InChI=1S/C19H17N4O2.BrH/c24-23(25)19-20-10-13-21(19)11-5-12-22-14-15-6-1-2-7-16(15)17-8-3-4-9-18(17)22;/h1-4,6-10,13-14H,5,11-12H2;1H/q+1;/p-1
SMILES Code
O=[N+](C1=NC=CN1CCC[N+]2=CC3=CC=CC=C3C4=C2C=CC=C4)[O-].[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 413.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Panicucci R, Heal R, Laderoute K, Cowan D, McClelland RA, Rauth AM. NLP-1: a DNA intercalating hypoxic cell radiosensitizer and cytotoxin. Int J Radiat Oncol Biol Phys. 1989 Apr;16(4):1039-43. PubMed PMID: 2703383. 2: Cowan DS, McClelland RA, Rauth AM. Isolation and characterization of a cell line resistant to 5-[3-(2-nitro-1-imidazoyl)-propyl]-phenanthridinium bromide (2-NLP-3), a DNA-intercalating hypoxic cell radiosensitizer and cytotoxin. Biochem Pharmacol. 1995 Jun 29;50(1):61-8. PubMed PMID: 7605346. 3: Buchko GW, Weinfeld M. DNA-targeted 2-nitroimidazoles: studies of the influence of the phenanthridine-linked nitroimidazoles, 2-NLP-3 and 2-NLP-4, on DNA damage induced by ionizing radiation. Radiat Res. 2002 Sep;158(3):302-10. PubMed PMID: 12175307. 4: Cowan DS, Kanagasabapathy VM, McClelland RA, Rauth AM. Mechanistic studies of enhanced in vitro radiosensitization and hypoxic cell cytotoxicity by targeting radiosensitizers to DNA via intercalation. Int J Radiat Oncol Biol Phys. 1992;22(3):541-4. PubMed PMID: 1735693. 5: Cowan DS, Matejovic JF, Wardman P, McClelland RA, Rauth AM. Radiosensitizing and cytotoxic properties of DNA targeted phenanthridine-linked nitroheterocycles of varying electron affinities. Int J Radiat Biol. 1994 Dec;66(6):729-38. PubMed PMID: 7814971.