Tetrahydromethotrexate | CAS#4299-28-9 | folic acid derivative

MedKoo Cat#: 597168 | Name: Tetrahydromethotrexate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tetrahydromethotrexate is a folic acid derivative.

Chemical Structure

Tetrahydromethotrexate

CAS#4299-28-9

Theoretical Analysis

MedKoo Cat#: 597168

Name: Tetrahydromethotrexate

CAS#: 4299-28-9

Chemical Formula: C20H26N8O5

Exact Mass: 458.2026

Molecular Weight: 458.47

Elemental Analysis: C, 52.39; H, 5.72; N, 24.44; O, 17.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Tetrahydromethotrexate; NSC 526044; NSC-526044; NSC526044;

IUPAC/Chemical Name

(4-(((2,4-diamino-5,6,7,8-tetrahydropteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid

InChi Key

GLSBTKIRCIEEJO-YUZLPWPTSA-N

InChi Code

InChI=1S/C20H26N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,11,13,24H,6-9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H5,21,22,23,26,27)/t11?,13-/m0/s1

SMILES Code

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2NC3=C(N)N=C(N)N=C3NC2)C)C=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 458.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Makulu DR, Fölsch E. Reduced forms of aminopterin and methotrexate in L1210 lymphoma. J Natl Cancer Inst. 1977 Jul;59(1):245-9. PubMed PMID: 875056. 2: Bühring U, Shin YS, Fölsch E. The influence of folate antagonists on the metabolism of folic acid and its reduced derivatives in rat liver and kidney. Cancer Res. 1977 Jan;37(1):299-304. PubMed PMID: 830415. 3: Slavík K, Rode W, Slavíková V. Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography. Biochemistry. 1976 Sep 21;15(19):4222-7. PubMed PMID: 786369. 4: Blair JA, Saunders KJ. Preparation of analogs of dl-tetrahydromethotrexate (4-amino-4-deoxy-N10-methyl-dl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acid). Anal Biochem. 1971 Jun;41(2):482-6. PubMed PMID: 5092165.