Atropine Oxide Hydrochloride | CAS#4574-60-1 | atropine derivative

MedKoo Cat#: 593049 | Name: Atropine Oxide Hydrochloride

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Atropine Oxide is a derivative of Atropine. Atropine is a medication to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate and to decrease saliva production during surgery. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. It is classified as an anticholinergic drug (parasympatholytic).

Chemical Structure

Atropine Oxide Hydrochloride

CAS#4574-60-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 593049

Name: Atropine Oxide Hydrochloride

CAS#: 4574-60-1 (HCl)

Chemical Formula: C17H24ClNO4

Exact Mass: 341.1394

Molecular Weight: 341.83

Elemental Analysis: C, 59.73; H, 7.08; Cl, 10.37; N, 4.10; O, 18.72

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 685.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

4574-60-1 (HCl) 4438-22-6 (free base)

Synonym

Atropine Oxide Hydrochloride

IUPAC/Chemical Name

Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, 8-oxide, hydrochloride, endo-(+-)-

InChi Key

QTRBWTMEQQSFLO-ICPLZUBISA-N

InChi Code

InChI=1S/C17H23NO4.ClH/c1-18(21)13-7-8-14(18)10-15(9-13)22-17(20)16(11-19)12-5-3-2-4-6-12;/h2-6,13-16,19H,7-11H2,1H3;1H/t13-,14+,15?,16?,18?;

SMILES Code

Cl.C[N+]1([O-])[C@H]2CC[C@@H]1CC(C2)OC(=O)C(CO)c3ccccc3

Appearance

Solid powder

Purity

>90% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 341.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schittkowski MP, Sturm V. Atropin zur Prävention der Myopieprogression – Datenlage, Nebenwirkungen, praktische Empfehlungen [Atropine for the Prevention of Progression in Myopia - Data, Side Effects, Practical Guidelines]. Klin Monbl Augenheilkd. 2018 Apr;235(4):385-391. German. doi: 10.1055/s-0043-121982. Epub 2017 Dec 21. PMID: 29270929. 2: LIST WF, GRAVENSTEIN JS. ATROPIN UND SCOPOLAMIN [ATROPINE AND SCOPOLAMINE]. Anaesthesist. 1965 May;14:154-6. German. PMID: 14303299. 3: Montastruc JL, Tran MA. Atropine [Atropine]. Rev Prat. 1998 Jan 1;48(1):85-7. French. PMID: 9781216. 4: Blumenberg D. Atropin [Atropine]. Krankenpfl J. 1987 Jan-Feb;25(1-2):27-8. German. PMID: 3645165. 5: Lakstygal AM, Kolesnikova TO, Khatsko SL, Zabegalov KN, Volgin AD, Demin KA, Shevyrin VA, Wappler-Guzzetta EA, Kalueff AV. DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens. ACS Chem Neurosci. 2019 May 15;10(5):2144-2159. doi: 10.1021/acschemneuro.8b00615. Epub 2019 Jan 10. PMID: 30566832. 6: Rosborough JP. Atropine: animal models. Ann Emerg Med. 1984 Sep;13(9 Pt 2):813-5. doi: 10.1016/s0196-0644(84)80446-1. PMID: 6476548. 7: Manzo M. Atropine--a versatile drug. Nursing. 1988 Nov;18(11):24. doi: 10.1097/00152193-198811000-00017. PMID: 3211411. 8: Kwakye GF, Jiménez J, Jiménez JA, Aschner M. Atropa belladonna neurotoxicity: Implications to neurological disorders. Food Chem Toxicol. 2018 Jun;116(Pt B):346-353. doi: 10.1016/j.fct.2018.04.022. Epub 2018 Apr 10. PMID: 29653183. 9: Hagelsten JO. Atropin [Atropine]. Ugeskr Laeger. 1994 May 16;156(20):3051-2. Danish. PMID: 8023418. 10: Srinivasan P, Smolke CD. Biosynthesis of medicinal tropane alkaloids in yeast. Nature. 2020 Sep;585(7826):614-619. doi: 10.1038/s41586-020-2650-9. Epub 2020 Sep 2. PMID: 32879484; PMCID: PMC7529995. 11: Kaymak H, Mattern AI, Graff B, Neller K, Langenbucher A, Seitz B, Schwahn H. Safety of DIMS Spectacle Lenses and Atropine as Combination Therapy for Myopia Progression. Klin Monbl Augenheilkd. 2022 Oct;239(10):1197-1205. doi: 10.1055/a-1930-7116. Epub 2022 Aug 25. PMID: 36008055; PMCID: PMC9578763. 12: Zsigmond EK, Matsuki A, Sharafabadi C. Atropine and cardiac arrhythmia. N Engl J Med. 1973 Mar 22;288(12):635. doi: 10.1056/NEJM197303222881217. PMID: 4686993. 13: Dräger B. Wie kommt Atropin in die Tollkirsche? Neues zur Regulation des pflanzlichen Sekundärstoffwechsels [How is atropine made in belladonna? New findings on the regulation of plant secondary metabolites]. Pharm Unserer Zeit. 1996 Sep;25(5):242-9. German. doi: 10.1002/pauz.19960250507. PMID: 8984502. 14: Thiermann H, Steinritz D, Worek F, Radtke M, Eyer P, Eyer F, Felgenhauer N, Zilker T. Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning. Toxicol Lett. 2011 Sep 25;206(1):77-83. doi: 10.1016/j.toxlet.2011.07.006. Epub 2011 Jul 8. PMID: 21771644. 15: Van der Meer MJ, Hundt HK, Müller FO. The metabolism of atropine in man. J Pharm Pharmacol. 1986 Oct;38(10):781-4. doi: 10.1111/j.2042-7158.1986.tb04494.x. PMID: 2879005. 16: Scherf D. Atropine in acute myocardial infarction. Am Heart J. 1973 Aug;86(2):284. doi: 10.1016/0002-8703(73)90261-5. PMID: 4719950. 17: Amitai Y, Almog S, Singer R, Hammer R, Bentur Y, Danon YL. Atropine poisoning in children during the Persian Gulf crisis. A national survey in Israel. JAMA. 1992 Aug 5;268(5):630-2. PMID: 1629992. 18: Mathis U, Feldkaemper MP, Schaeffel F. Effects of Single and Repeated Intravitreal Applications of Atropine on Choroidal Thickness in Alert Chickens. Ophthalmic Res. 2021;64(4):664-674. doi: 10.1159/000515755. Epub 2021 Mar 30. PMID: 33774636. 19: Bendtsen A. Indikation for praeoperativ atropin-indgift [Indication for preoperative administration of atropine]. Ugeskr Laeger. 1980 Aug 4;142(32):2045-7. Danish. PMID: 6996264. 20: Virtanen R, Kanto J, Iisalo E. Radioimmunoassay for atropine and l-hyoscyamine. Acta Pharmacol Toxicol (Copenh). 1980 Sep;47(3):208-12. doi: 10.1111/j.1600-0773.1980.tb01561.x. PMID: 7446137.