Pemedolac sodium | CAS#148129-69-5 | Analgesic

MedKoo Cat#: 573357 | Name: Pemedolac sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pemedolac, also known as Dexpemedolac and AY-30,715, is a potent analgesic agent. Pemedolac exhibited potent analgesic effects against chemically induced pain in rats and mice and against inflammatory pain in rats. Pemedolac differed from standard nonsteroidal anti-inflammatory drugs (NSAIDs) in that the doses which produced analgesia were much lower than those required for either anti-inflammatory or gastric irritant effects.

Chemical Structure

Pemedolac sodium

CAS#148129-69-5 (sodium)

Theoretical Analysis

MedKoo Cat#: 573357

Name: Pemedolac sodium

CAS#: 148129-69-5 (sodium)

Chemical Formula: C22H22NNaO3

Exact Mass: 349.1678

Molecular Weight: 371.41

Elemental Analysis: C, 71.15; H, 5.97; N, 3.77; Na, 6.19; O, 12.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

148129-69-5 (sodium) 114716-16-4 (free acid) 114030-44-3 114030-45-4

Synonym

AY-30,715; AY 30,715; AY30,715; AY-30715; AY 30715; AY30715; pemedolac; WAY-PEM-420; Dexpemedolac

IUPAC/Chemical Name

Pyrano[3,4-b]indole-1-acetic acid, 1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)-, sodium salt (1:1), (1R,4S)-rel-

InChi Key

FRXLWASFNBDPHC-BYYQELCVSA-M

InChi Code

InChI=1S/C22H23NO3.Na/c1-2-22(13-19(24)25)21-20(17-10-6-7-11-18(17)23-21)16(14-26-22)12-15-8-4-3-5-9-15;/h3-11,16,23H,2,12-14H2,1H3,(H,24,25);/q;+1/p-1/t16-,22-;/m1./s1

SMILES Code

O=C([O-])C[C@@]1(CC)OC[C@@H](CC2=CC=CC=C2)C3=C1NC4=C3C=CC=C4.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 371.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Catalano A, Iacopetta D, Ceramella J, Saturnino C, Sinicropi MS. A Comprehensive Review on Pyranoindole-containing Agents. Curr Med Chem. 2022;29(21):3667-3683. doi: 10.2174/0929867328666211206111058. PMID: 34872472. 2: Chau T, Walter T, Zimmerman J, Hartman D, Ochalski S, Weichman B. Analgesic activities of PEM-420, the active eutomer of pemedolac. Agents Actions. 1993;39 Spec No:C27-9. doi: 10.1007/BF01972710. PMID: 8273576. 3: Chau TT, Weichman BM. Pemedolac: a novel and long-acting non-narcotic analgesic. J Pharmacol Exp Ther. 1989 Mar;248(3):907-15. PMID: 2703977. 4: Mobilio D, Humber LG, Katz AH, Demerson CA, Hughes P, Brigance R, Conway K, Shah U, Williams G, Labbadia F, et al. Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indo le-1-a cetic acid, a potent analgesic agent. J Med Chem. 1988 Nov;31(11):2211-7. doi: 10.1021/jm00119a024. PMID: 3263504. 5: Katz AH, Demerson CA, Shaw CC, Asselin AA, Humber LG, Conway KM, Gavin G, Guinosso C, Jensen NP, Mobilio D, et al. Synthesis and analgesic activity of pemedolac (cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]ind ole-1- acetic acid). J Med Chem. 1988 Jun;31(6):1244-50. doi: 10.1021/jm00401a029. PMID: 3373493.