GSK 2239633A | CAS# 1240516-71-5

MedKoo Cat#: 471038 | Name: GSK 2239633A

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK 2239633A, is a potent CCR4 antagonist.

Chemical Structure

GSK 2239633A

CAS#1240516-71-5

Theoretical Analysis

MedKoo Cat#: 471038

Name: GSK 2239633A

CAS#: 1240516-71-5

Chemical Formula: C24H25ClN4O5S2

Exact Mass: 548.0955

Molecular Weight: 549.06

Elemental Analysis: C, 52.50; H, 4.59; Cl, 6.46; N, 10.20; O, 14.57; S, 11.68

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 450.00	2 Weeks
100mg	USD 850.00	2 Weeks

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Synonym

GSK 2239633A; GSK2239633A; GSK-2239633A; GSK-2239633; GSK2239633; GSK 2239633;

IUPAC/Chemical Name

N-[[3-[[3-[[(5-Chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methylpropanamide

InChi Key

YTEVTHHGQMUPHC-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H25ClN4O5S2/c1-24(2,31)23(30)26-13-15-6-4-7-16(12-15)14-29-17-8-5-9-18(34-3)21(17)22(27-29)28-36(32,33)20-11-10-19(25)35-20/h4-12,31H,13-14H2,1-3H3,(H,26,30)(H,27,28)

SMILES Code

CC(C)(O)C(NCC1=CC=CC(CN2N=C(NS(=O)(C3=CC=C(Cl)S3)=O)C4=C2C=CC=C4OC)=C1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	152.5	277.67

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 549.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1. Procopiou PA. et al.; Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation; Bioorg Med Chem Lett. 2012 Apr 15;22(8):2730-3