Sclareol glycol | CAS#38419-75-9 | Anti-hypoxia agent

MedKoo Cat#: 581718 | Name: Sclareol glycol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sclareol glycol is a reversible activator of adenylate cyclase sclareol glycol (SG), a semisynthetic diterpene of the labdane family. Anti-hypoxia agent.

Chemical Structure

Sclareol glycol

CAS#38419-75-9

Theoretical Analysis

MedKoo Cat#: 581718

Name: Sclareol glycol

CAS#: 38419-75-9

Chemical Formula: C16H30O2

Exact Mass: 254.2246

Molecular Weight: 254.41

Elemental Analysis: C, 75.54; H, 11.89; O, 12.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Sclareol glycol; Decahydro-2-hydroxy-2,5,5,8a-tetramethylnaphthalene-1-ethanol.

IUPAC/Chemical Name

(1R,2S,4aR,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol

InChi Key

AIALTZSQORJYNJ-VDERGJSUSA-N

InChi Code

InChI=1S/C16H30O2/c1-14(2)8-5-9-15(3)12(14)6-10-16(4,18)13(15)7-11-17/h12-13,17-18H,5-11H2,1-4H3/t12-,13-,15+,16+/m1/s1

SMILES Code

OCC[C@@H]1[C@@]2([C@@H](C(CCC2)(C)C)CC[C@@]1(O)C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 254.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang X, Zhang X, Yao Q, Hua D, Qin J. Comparative proteomic analyses of Hyphozyma roseonigra ATCC 20624 in response to sclareol. Braz J Microbiol. 2019 Jan 15. doi: 10.1007/s42770-019-00040-2. [Epub ahead of print] PubMed PMID: 30645731. 2: Wang X, Zhang X, Yao Q, Hua D, Qin J. Comparative proteomic analyses of Hyphozyma roseonigra ATCC 20624 in response to sclareol. Braz J Microbiol. 2018 Nov;49 Suppl 1:160-165. doi: 10.1016/j.bjm.2018.04.001. Epub 2018 Apr 24. PubMed PMID: 29773508; PubMed Central PMCID: PMC6328719. 3: Georgieva JV. Influences of diterpene sclareol glycol on some dopamine related behavior. Gen Pharmacol. 1991;22(2):331-5. PubMed PMID: 2055429. 4: Georgieva J, Danchev N. The effects of the diterpene sclareol glycol on seizures do not depend on central benzodiazepine receptors. Methods Find Exp Clin Pharmacol. 1990 Dec;12(10):679-83. PubMed PMID: 1966111. 5: Georgieva J. The response of diterpene sclareol glycol to acute hypoxia in mice. Methods Find Exp Clin Pharmacol. 1990 Nov;12(9):591-3. PubMed PMID: 2084452. 6: Astardzhieva Z, Stoichkov I. [The effect of sclareol lactone and sclareol glycol on artificially induced lung metastases of Lewis lung carcinoma (a preliminary report)]. Eksp Med Morfol. 1990;29(3):58-61. Bulgarian. PubMed PMID: 2276380. 7: Georgieva J. Measures of anxiety, retention and stress in the rat following treatment with the diterpene sclareol glycol. Methods Find Exp Clin Pharmacol. 1990 Jan-Feb;12(1):5-10. PubMed PMID: 2156119. 8: Georgieva JV. Diterpene sclareol glycol inhibits clonidine-induced aggressive responses in mice. Pharmacol Biochem Behav. 1989 Nov;34(3):503-5. PubMed PMID: 2623007. 9: Georgieva J. Effects of the diterpene sclareol glycol on convulsive seizures. Methods Find Exp Clin Pharmacol. 1989 May;11(5):335-40. PubMed PMID: 2755280. 10: Georgieva J. Effects of the diterpene sclareol glycol on body temperature in rats. Methods Find Exp Clin Pharmacol. 1989 Apr;11(4):277-80. PubMed PMID: 2755274. 11: Georgieva Zh. [Study of the effect of sclareol glycol diterpene on the release of adenohypophysial hormones prolactin, somatotropin and adenocorticotrophic hormone]. Eksp Med Morfol. 1989;28(3):7-14. Bulgarian. PubMed PMID: 2553392. 12: Georgieva Zh, Uzunov P. [Study of the effect of sclareol glycol diterpene on the 3',5'-AMP level]. Eksp Med Morfol. 1989;28(3):1-7. Bulgarian. PubMed PMID: 2553391. 13: Rangelov A, Kossev P, Malakov P. Experimental study of essential oils from two varieties of cultivated thyme, sesquiterpene Germacron and diterpene Sclareol for cholagogic and choleretic activity. Folia Med (Plovdiv). 1989;31(3):34-8. PubMed PMID: 2490810. 14: Georgieva Zh. [Effect of diterpene sklareol glycol on the conflict test and its correlation with diazepam]. Eksp Med Morfol. 1988;27(4):35-8. Bulgarian. PubMed PMID: 3234308. 15: Georgieva Zh, Ognianov I, Uzunov P, Ovcharov R. [Effects of sklareol-glycol on pentylenetetrazole-induced convulsions and its interaction with diazepam]. Eksp Med Morfol. 1987;26(1):28-31. Bulgarian. PubMed PMID: 3595495.