CCR6 antagonist 1 is a small-molecule inhibitor that selectively targets the C-C chemokine receptor 6 (CCR6), a G protein-coupled receptor involved in immune cell trafficking and inflammation. By blocking CCR6 signaling, this antagonist interferes with the migration of Th17 cells and dendritic cells, which play a key role in autoimmune diseases and inflammatory responses. This mechanism makes CCR6 antagonist 1 a potential therapeutic candidate for conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease.
MedKoo Cat#: 556185
Name: CCR6 antagonist 1
CAS#: 588674-64-0
Chemical Formula: C17H12F3NO2
Exact Mass: 319.0820
Molecular Weight: 319.28
Elemental Analysis: C, 63.95; H, 3.79; F, 17.85; N, 4.39; O, 10.02
The following data is based on the product molecular weight 319.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
