Synonym
Disophenol; BRN2052233; BRN-2052233; BRN 2052233
IUPAC/Chemical Name
2,6-Diiodo-4-nitrophenol
InChi Key
UVGTXNPVQOQFQW-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H3I2NO3/c7-4-1-3(9(11)12)2-5(8)6(4)10/h1-2,10H
SMILES Code
OC1=C(I)C=C([N+]([O-])=O)C=C1I
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Disophenol is a drug used in veterinary medicine recommended for use in the treatment of dogs infested with hook worms.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
390.90
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Martin CL. The formation of cataracts in dogs with disophenol: age susceptibility and production with chemical grade, 2,6-diiodo-4-nitrophenol. Can Vet J. 1975 Aug;16(8):228-32. PMID: 1156997; PMCID: PMC1697004.
2: SENEVIRATNA P, FERNANDO ST, DHANAPALA SB. DISOPHENOL IN THE TREATMENT OF SPIROCERCA LUPI INFECTION IN DOGS. Vet Rec. 1965 Jul 3;77:798-9. PMID: 14331479.
3: Penumarthy L, Oehme FW, Menhusen MJ. Investigations of therapeutic measures for disophenol toxicosis in dogs. Am J Vet Res. 1975 Aug;36(08):1259-62. PMID: 1155844.
4: Driemeier D, Schild AL, Fernandes JC, Colodel EM, Corrêa AM, Cruz CE, Barros CS. Outbreaks of tetanus in beef cattle and sheep in Brazil associated with disophenol injection. J Vet Med A Physiol Pathol Clin Med. 2007 Aug;54(6):333-5. doi: 10.1111/j.1439-0442.2007.00922.x. PMID: 17650154.
5: Legendre AM. Disophenol toxicosis in a dog. J Am Vet Med Assoc. 1973 Jul 15;163(2):149-50. PMID: 4717119.
6: WOOD IB, PANKAVICH JA, WALL ACE WS, THORSON RE, BURKHART RL, WALETZKY E. Disophenol, an injectable anthelmintic for canine hookworms. J Am Vet Med Assoc. 1961 Nov 15;139:1101-5. PMID: 14008172.
7: Soetedjo R, Beriajaya D, Henderson AW, Kelly JD. Use of disophenol for the control of Haemonchus contortus in sheep in West Java, Indonesia. Trop Anim Health Prod. 1980 Nov;12(4):198-202. doi: 10.1007/BF02236616. PMID: 7456119.
8: Hall CA, Kelly JD, Whitlock HV, Ritchie L. Prolonged anthelmintic effect of closantel and disophenol against a thiabendazole selected resistant strain of Haemonchus contortus in sheep. Res Vet Sci. 1981 Jul;31(1):104-6. PMID: 7313310.
9: Seneviratna P, Fernando ST, Dhanapala SB. Disophenol treatment of spirocercosis in dogs. J Am Vet Med Assoc. 1966 Feb 1;148(3):269-74. PMID: 5912098.
10: Lyons ET, Kim KC, Keyes MC. Variable activity of disophenol against hookworms and lice of northern fur seal pups on St. Paul Island, Alaska. J Wildl Dis. 1980 Jan;16(1):53-7. doi: 10.7589/0090-3558-16.1.53. PMID: 7373724.
