T-808 | CAS# 1320211-61-7 | Tau PET-Tracer

MedKoo Cat#: 573334 | Name: T-808

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T-808 is a tau tracer which may be used in radiographic labeling of Tau aggregates during Alzheimer's disease.

Chemical Structure

T-808

CAS#1320211-61-7

Theoretical Analysis

MedKoo Cat#: 573334

Name: T-808

CAS#: 1320211-61-7

Chemical Formula: C17H19FN4

Exact Mass: 298.1594

Molecular Weight: 298.37

Elemental Analysis: C, 68.44; H, 6.42; F, 6.37; N, 18.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

AVI-680, T-808, T808

IUPAC/Chemical Name

Pyrimido(1,2-a)benzimidazole, 2-(4-(2-fluoroethyl)-1-piperidinyl)-

InChi Key

DWSFKWXDRBTTCG-UHFFFAOYSA-N

InChi Code

1S/C17H19FN4/c18-9-5-13-6-10-21(11-7-13)16-8-12-22-15-4-2-1-3-14(15)19-17(22)20-16/h1-4,8,12-13H,5-7,9-11H2

SMILES Code

c1ccc2c(c1)nc3n2ccc(n3)N4CCC(CC4)CCF

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 298.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Honer M, Gobbi L, Knust H, Kuwabara H, Muri D, Koerner M, Valentine H, Dannals RF, Wong DF, Borroni E. Preclinical Evaluation of (18)F-RO6958948, (11)C-RO6931643, and (11)C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease. J Nucl Med. 2018 Apr;59(4):675-681. doi: 10.2967/jnumed.117.196741. Epub 2017 Sep 28. PubMed PMID: 28970331; PubMed Central PMCID: PMC5932750. 2: Declercq L, Celen S, Lecina J, Ahamed M, Tousseyn T, Moechars D, Alcazar J, Ariza M, Fierens K, Bottelbergs A, Mariën J, Vandenberghe R, Andres IJ, Van Laere K, Verbruggen A, Bormans G. Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807. Mol Imaging. 2016 Jan 27;15. pii: 1536012115624920. doi: 10.1177/1536012115624920. Print 2016. PubMed PMID: 27030397; PubMed Central PMCID: PMC5470083. 3: Gao M, Wang M, Zheng QH. Concise and high-yield synthesis of T808 and T808P for radiosynthesis of [(18)F]-T808, a PET tau tracer for Alzheimer's disease. Bioorg Med Chem Lett. 2014 Jan 1;24(1):254-7. doi: 10.1016/j.bmcl.2013.11.025. Epub 2013 Nov 20. PubMed PMID: 24309505. 4: Chien DT, Szardenings AK, Bahri S, Walsh JC, Mu F, Xia C, Shankle WR, Lerner AJ, Su MY, Elizarov A, Kolb HC. Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808. J Alzheimers Dis. 2014;38(1):171-84. doi: 10.3233/JAD-130098. PubMed PMID: 23948934.