JX-35 HCl | CAS#unknown | HDAC1 Inhibitor

MedKoo Cat#: 465828 | Name: JX-35 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JX-35 is a Novel Plasmodium falciparum HDAC1 Inhibitor with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. JX35 showed potent inhibition against both wild-type and multidrug-resistant parasite strains and displayed a significant in vivo killing effect against all life cycles of parasites, including the blood stage, liver stage, and gametocyte stage, indicating its potential for the simultaneous treatment, chemoprevention, and blockage of malaria transmission.

Chemical Structure

JX-35 HCl

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465828

Name: JX-35 HCl

CAS#: unknown

Chemical Formula: C22H24ClN7O2

Exact Mass: 453.1680

Molecular Weight: 453.93

Elemental Analysis: C, 58.21; H, 5.33; Cl, 7.81; N, 21.60; O, 7.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JX-35 HCl; JX35 HCl; JX 35 HCl; JX-35 hydrochloride; JX35 hydrochloride; JX 35 hydrochloride;

IUPAC/Chemical Name

2-(2-((6-cyano-1-methyl-1H-indol-3-yl)methyl)-2,6-diazaspiro[3.4]octan-6-yl)-N-hydroxypyrimidine-5-carboxamide hydrochloride

InChi Key

NPDHHPIUUWFZPB-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H23N7O2.ClH/c1-27-10-17(18-3-2-15(7-23)6-19(18)27)11-28-12-22(13-28)4-5-29(14-22)21-24-8-16(9-25-21)20(30)26-31;/h2-3,6,8-10,31H,4-5,11-14H2,1H3,(H,26,30);1H

SMILES Code

O=C(NO)C1=CN=C(N2CC3(CN(CC4=CN(C)C5=C4C=CC(C#N)=C5)C3)CC2)N=C1.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 453.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang B, Cheng K, Zhang L, Huang Y, Liu C. Marinactinospora rubrisoli sp. nov., isolated from red soil. Arch Microbiol. 2019 May;201(4):459-465. doi: 10.1007/s00203-018-1583-2. Epub 2018 Oct 8. PMID: 30298376. 2: Wang M, Tang T, Li R, Huang Z, Ling D, Zheng L, Ding Y, Liu T, Xu W, Zhu F, Min H, Boonhok R, Mao F, Zhu J, Li X, Jiang L, Li J. Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety. J Med Chem. 2022 Feb 17. doi: 10.1021/acs.jmedchem.1c01993. Epub ahead of print. PMID: 35175762. 3: Chen JY, Penn LS, Xi J. Quartz crystal microbalance: Sensing cell-substrate adhesion and beyond. Biosens Bioelectron. 2018 Jan 15;99:593-602. doi: 10.1016/j.bios.2017.08.032. Epub 2017 Aug 15. PMID: 28830033. 4: Chen JY, Pan Y, Collins TJ, Penn LS, Xi N, Xi J. Examining the feasibility of a "top-down" approach to enhancing the keratinocyte-implant adhesion. Exp Cell Res. 2019 Mar 15;376(2):105-113. doi: 10.1016/j.yexcr.2019.01.024. Epub 2019 Feb 14. PMID: 30772381. 5: Garcia MP, Shahid A, Chen JY, Xi J. Evaluating Inhibition of the Epidermal Growth Factor (EGF)-Induced Response of Mutant MCF10A Cells with an Acoustic Sensor. Biosensors (Basel). 2012 Nov 13;2(4):448-64. doi: 10.3390/bios2040448. PMID: 25586035; PMCID: PMC4263556.