MedKoo Cat#: 575858 | Name: Ziprasidone mesylate trihydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ziprasidone mesylate trihydrate is a benzisothiazoylpiperazine derivative with combined dopamine and serotonin receptor antagonist activity.

Chemical Structure

Ziprasidone mesylate trihydrate
Ziprasidone mesylate trihydrate
CAS#199191-69-0 (mesylate trihydrate)

Theoretical Analysis

MedKoo Cat#: 575858

Name: Ziprasidone mesylate trihydrate

CAS#: 199191-69-0 (mesylate trihydrate)

Chemical Formula: C22H31ClN4O7S2

Exact Mass: 562.1323

Molecular Weight: 563.08

Elemental Analysis: C, 46.93; H, 5.55; Cl, 6.30; N, 9.95; O, 19.89; S, 11.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
CP-88, 059-27; Geodon; Ziprasidone mesylate trihydrate
IUPAC/Chemical Name
2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-, monomethanesulfonate, trihydrate
InChi Key
WLQZEFFFIUHSJB-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H21ClN4OS.CH4O3S.3H2O/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;1-5(2,3)4;;;/h1-4,11,13H,5-10,12H2,(H,23,27);1H3,(H,2,3,4);3*1H2
SMILES Code
O.O.O.CS(=O)(=O)O.Clc1cc2NC(=O)Cc2cc1CCN3CCN(CC3)c4nsc5ccccc45
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 563.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bouchette D, Pellegrini MV. Ziprasidone. 2017 Oct 9. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2017 Jun-. Available from http://www.ncbi.nlm.nih.gov/books/NBK448157/ PubMed PMID: 28846230. 2: Mandrioli R, Protti M, Mercolini L. Evaluation of the pharmacokinetics, safety and clinical efficacy of ziprasidone for the treatment of schizophrenia and bipolar disorder. Expert Opin Drug Metab Toxicol. 2015 Jan;11(1):149-74. doi: 10.1517/17425255.2015.991713. Epub 2014 Dec 6. Review. PubMed PMID: 25483358. 3: Lee HB, Yoon BH, Kwon YJ, Woo YS, Lee JG, Kim MD, Bahk WM. The efficacy and safety of switching to ziprasidone from olanzapine in patients with bipolar I disorder: an 8-week, multicenter, open-label study. Clin Drug Investig. 2013 Oct;33(10):743-53. doi: 10.1007/s40261-013-0120-y. Review. PubMed PMID: 23990283. 4: Andrade C. Antidepressant action of atypical antipsychotics: focus on ziprasidone monotherapy, with a few twists in the tale. J Clin Psychiatry. 2013 Mar;74(3):e193-6. doi: 10.4088/JCP.13f08410. Review. PubMed PMID: 23561239. 5: Pappadopulos E, Newcomer JW, Kolluri S. Changes in weight, plasma lipids, and glucose in adults treated with ziprasidone: a comprehensive analysis of pfizer-initiated clinical trials. J Clin Psychiatry. 2012 Jun;73(6):e742-8. doi: 10.4088/JCP.10r06802. Review. PubMed PMID: 22795213.