Synonym
HaloPROTAC-3; HaloPROTAC 3; Halo PROTAC-3; HaloPROTAC3; VH285-PEG4-C4-Cl
IUPAC/Chemical Name
(2S,4R)-N-(2-(2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)ethoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide
InChi Key
UABTZMQNIWDHGQ-JGNAJVFASA-N
InChi Code
InChI=1S/C41H55ClN4O8S/c1-28(2)37(46-25-32-10-6-7-11-34(32)40(46)49)41(50)45-26-33(47)23-35(45)39(48)43-24-31-13-12-30(38-29(3)44-27-55-38)22-36(31)54-21-20-53-19-18-52-17-16-51-15-9-5-4-8-14-42/h6-7,10-13,22,27-28,33,35,37,47H,4-5,8-9,14-21,23-26H2,1-3H3,(H,43,48)/t33-,35+,37+/m1/s1
SMILES Code
O=C([C@H]1N(C([C@@H](N(CC2=C3C=CC=C2)C3=O)C(C)C)=O)C[C@H](O)C1)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCCOCCOCCOCCCCCCCl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
799.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Caine EA, Mahan SD, Johnson RL, Nieman AN, Lam N, Warren CR, Riching KM, Urh
M, Daniels DL. Targeted Protein Degradation Phenotypic Studies Using HaloTag
CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3. Curr Protoc Pharmacol.
2020 Dec;91(1):e81. doi: 10.1002/cpph.81. PMID: 33332748; PMCID: PMC7818660.
2: Ortiz Zacarías NV, Röth S, Broekhuis JD, van der Es D, Moreau K, Heitman LH.
Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine
Receptor 2 (CCR2). Int J Mol Sci. 2024 Aug 18;25(16):8984. doi:
10.3390/ijms25168984. PMID: 39201670; PMCID: PMC11354370.
3: Tovell H, Testa A, Maniaci C, Zhou H, Prescott AR, Macartney T, Ciulli A,
Alessi DR. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal
Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019 May
17;14(5):882-892. doi: 10.1021/acschembio.8b01016. Epub 2019 Apr 22. PMID:
30978004; PMCID: PMC6528276.
