Kevetrin Free Base | CAS# 500863-50-3 (free base) | antineoplastic activity

MedKoo Cat#: 414230 | Name: Kevetrin Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kevetrin Free Base is a small molecule that has demonstrated the potential of becoming a breakthrough cancer treatment by inducing activation of p53, a protein frequently referred to as the “Guardian of the Genome” due to its critical role in controlling cell mutations. I

Chemical Structure

Kevetrin Free Base

CAS#500863-50-3 (free base)

Theoretical Analysis

MedKoo Cat#: 414230

Name: Kevetrin Free Base

CAS#: 500863-50-3 (free base)

Chemical Formula: C5H9N3S

Exact Mass: 143.0517

Molecular Weight: 143.21

Elemental Analysis: C, 41.94; H, 6.33; N, 29.34; S, 22.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

500863-50-3 (free base) 66592-89-0 (HCl)

Synonym

Kevetrin Free Base; NSC525990; NSC 525990; NSC-525990

IUPAC/Chemical Name

3-cyanopropyl carbamimidothioate

InChi Key

PRDJGNVQBVXXEO-UHFFFAOYSA-N

InChi Code

InChI=1S/C5H9N3S/c6-3-1-2-4-9-5(7)8/h1-2,4H2,(H3,7,8)

SMILES Code

NC(SCCCC#N)=N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

NCI: thioureidobutyronitrile. A water-soluble, molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. (NCI Thesaurus)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 143.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Napolitano R, De Matteis S, Carloni S, Bruno S, Abbati G, Capelli L, Ghetti M, Bochicchio MT, Liverani C, Mercatali L, Calistri D, Cuneo A, Menon K, Musuraca G, Martinelli G, Simonetti G. Kevetrin induces apoptosis in TP53 wild‑type and mutant acute myeloid leukemia cells. Oncol Rep. 2020 Oct;44(4):1561-1573. doi: 10.3892/or.2020.7730. Epub 2020 Aug 11. PMID: 32945487; PMCID: PMC7448420.