K811 | CAS# 1355228-38-4 | ASK1 inhibitor

MedKoo Cat#: 465016 | Name: K811

Description:

WARNING: This product is for research use only, not for human or veterinary use.

K811 is an ASK1-specific inhibitor that prolongs survival in a mouse model of amyotrophic lateral sclerosis. K811 efficiently prevented cell proliferation in cell lines with high ASK1 expression and in HER2-overexpressing GC cells. Treatment with K811 reduced sizes of xenograft tumors by downregulating proliferation markers.

Chemical Structure

K811

CAS#1355228-38-4

Theoretical Analysis

MedKoo Cat#: 465016

Name: K811

CAS#: 1355228-38-4

Chemical Formula: C29H26N4O5

Exact Mass: 510.1903

Molecular Weight: 510.55

Elemental Analysis: C, 68.22; H, 5.13; N, 10.97; O, 15.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1355228-38-4; 1355228-39-5

Synonym

K811; K 811; K811

IUPAC/Chemical Name

N-(4-((6,7-dimethoxycinnolin-4-yl)oxy)phenyl)-1-isopropyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

InChi Key

JVQKIXBAOVAPKB-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H26N4O5/c1-17(2)33-16-22(28(34)20-7-5-6-8-24(20)33)29(35)31-18-9-11-19(12-10-18)38-27-15-30-32-23-14-26(37-4)25(36-3)13-21(23)27/h5-17H,1-4H3,(H,31,35)

SMILES Code

COC1=CC2=C(C=C1OC)C(OC3=CC=C(NC(C4=CN(C(C)C)C(C=CC=C5)=C5C4=O)=O)C=C3)=CN=N2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 510.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fujisawa T, Takahashi M, Tsukamoto Y, Yamaguchi N, Nakoji M, Endo M, Kodaira H, Hayashi Y, Nishitoh H, Naguro I, Homma K, Ichijo H. The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis. Hum Mol Genet. 2016 Jan 15;25(2):245-53. doi: 10.1093/hmg/ddv467. Epub 2015 Nov 24. PubMed PMID: 26604152. 2: Kawarazaki Y, Ichijo H, Naguro I. Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin Ther Targets. 2014 Jun;18(6):651-64. doi: 10.1517/14728222.2014.896903. Epub 2014 Mar 24. Review. PubMed PMID: 24660755. 3: Hayakawa Y, Hirata Y, Sakitani K, Nakagawa H, Nakata W, Kinoshita H, Takahashi R, Takeda K, Ichijo H, Maeda S, Koike K. Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer. Cancer Sci. 2012 Dec;103(12):2181-5. doi: 10.1111/cas.12024. Epub 2012 Oct 30. PubMed PMID: 23110662. 4: Jadhav TS, Wooten MW, Wooten MC. Mining the TRAF6/p62 interactome for a selective ubiquitination motif. BMC Proc. 2011 May 28;5 Suppl 2:S4. doi: 10.1186/1753-6561-5-S2-S4. PubMed PMID: 21554762; PubMed Central PMCID: PMC3090762. 5: Tchesnokov EP, Gilbert C, Boivin G, Götte M. Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet. J Virol. 2006 Feb;80(3):1440-50. PubMed PMID: 16415021; PubMed Central PMCID: PMC1346920. 6: Martorell L, Zaera MG, Valero J, Serrano D, Figuera L, Joven J, Labad A, Vilella E, Nunes V. The WFS1 (Wolfram syndrome 1) is not a major susceptibility gene for the development of psychiatric disorders. Psychiatr Genet. 2003 Mar;13(1):29-32. PubMed PMID: 12605098.