F-Chemotactic peptide-fluorescein | CAS#117576-09-7 | fluorescent label

MedKoo Cat#: 597586 | Name: F-Chemotactic peptide-fluorescein

Description:

WARNING: This product is for research use only, not for human or veterinary use.

F-Chemotactic peptide-fluorescein is a fluorescent label.

Chemical Structure

F-Chemotactic peptide-fluorescein

CAS#117576-09-7

Theoretical Analysis

MedKoo Cat#: 597586

Name: F-Chemotactic peptide-fluorescein

CAS#: 117576-09-7

Chemical Formula: C64H76N8O14S

Exact Mass: 1212.5202

Molecular Weight: 1213.41

Elemental Analysis: C, 63.35; H, 6.31; N, 9.23; O, 18.46; S, 2.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

F-Chemotactic peptide-fluorescein; Fnlpntl-fluorescein; N-Formyl-nle-leu-phe-nle-tyr-lys-fluorescein;

IUPAC/Chemical Name

N6-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-4-yl)carbamothioyl)-N2-(((S)-2-((S)-2-((S)-2-((S)-2-formamidohexanamido)-4-methylpentanamido)-3-phenylpropanamido)hexanoyl)-L-tyrosyl)-L-lysine

InChi Key

SZERHIDJPVWUOG-UTEXNEJUSA-N

InChi Code

InChI=1S/C64H76N8O14S/c1-5-7-18-47(66-36-73)56(77)69-50(31-37(3)4)58(79)71-51(32-38-15-10-9-11-16-38)59(80)67-48(19-8-6-2)57(78)70-52(33-39-22-24-40(74)25-23-39)60(81)68-49(61(82)83)20-12-13-30-65-63(87)72-46-21-14-17-45-55(46)62(84)86-64(45)43-28-26-41(75)34-53(43)85-54-35-42(76)27-29-44(54)64/h9-11,14-17,21-29,34-37,47-52,74-76H,5-8,12-13,18-20,30-33H2,1-4H3,(H,66,73)(H,67,80)(H,68,81)(H,69,77)(H,70,78)(H,71,79)(H,82,83)(H2,65,72,87)/t47-,48-,49-,50-,51-,52-/m0/s1

SMILES Code

O=C1OC2(c3ccc(O)cc3Oc4cc(O)ccc42)c5cccc(NC(NCCCC[C@@H](C(O)=O)NC([C@H](Cc6ccc(O)cc6)NC([C@H](CCCC)NC([C@H](Cc7ccccc7)NC([C@H](CC(C)C)NC([C@H](CCCC)NC=O)=O)=O)=O)=O)=O)=S)c15

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,213.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Werner K, Kälble S, Wolter S, Schneider EH, Buschauer A, Neumann D, Seifert R. Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor. Naunyn Schmiedebergs Arch Pharmacol. 2015 Oct;388(10):1039-52. doi: 10.1007/s00210-015-1133-2. Epub 2015 May 30. PubMed PMID: 26021872. 2: Coppi M, Niederman R. Effects of ammonia on human neutrophil N-formyl chemotactic peptide receptor-ligand interaction and cytoskeletal association. Biochem Biophys Res Commun. 1989 Nov 30;165(1):377-83. PubMed PMID: 2590235. 3: Øie CI, Snapkov I, Elvevold K, Sveinbjørnsson B, Smedsrød B. FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides. PLoS One. 2016 Aug 5;11(8):e0160602. doi: 10.1371/journal.pone.0160602. eCollection 2016. PubMed PMID: 27494406; PubMed Central PMCID: PMC4975464. 4: Hoffman JF, Keil ML, Riccobene TA, Omann GM, Linderman JJ. Interconverting receptor states at 4 degrees C for the neutrophil N-formyl peptide receptor. Biochemistry. 1996 Oct 8;35(40):13047-55. PubMed PMID: 8855940. 5: Hoffman JF, Linderman JJ, Omann GM. Receptor up-regulation, internalization, and interconverting receptor states. Critical components of a quantitative description of N-formyl peptide-receptor dynamics in the neutrophil. J Biol Chem. 1996 Aug 2;271(31):18394-404. PubMed PMID: 8702483.