p-MPPF is a high-affinity selective antagonist for the 5-HT₁A receptor, commonly used as a radioligand in PET imaging. It exhibits nanomolar binding affinity with reported Ki values ranging from 0.2 to 4.5 nM for 5-HT₁A receptors in vitro, depending on assay conditions and tissue sources. In binding studies using human or rodent brain tissue, p-MPPF shows high selectivity over other serotonin receptor subtypes and minimal off-target activity. Its fluorine-18-labeled analog, [¹⁸F]p-MPPF, crosses the blood-brain barrier efficiently and displays favorable kinetics for imaging 5-HT₁A receptor distribution in vivo, particularly in cortical and limbic brain regions, supporting its utility in neuropsychiatric research.
MedKoo Cat#: 596023
Name: p-MPPF free base
CAS#: 155204-26-5 (free base)
Chemical Formula: C25H27FN4O2
Exact Mass: 434.2110
Molecular Weight: 434.52
Elemental Analysis: C, 69.11; H, 6.26; F, 4.37; N, 12.89; O, 7.36
The following data is based on the product molecular weight 434.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
