Gliquidone is a second-generation sulfonylurea antidiabetic agent that acts primarily by stimulating insulin release from pancreatic β-cells. It exerts its bioactivity through high-affinity binding to the ATP-sensitive potassium (K_ATP) channels on β-cell membranes, particularly the SUR1 subunit, leading to channel closure, membrane depolarization, and subsequent opening of voltage-dependent calcium channels, thereby promoting insulin secretion. Reported EC₅₀ values for K_ATP channel inhibition range from 10 to 50 nM in isolated rat or mouse pancreatic islets, indicating high potency.
MedKoo Cat#: 573252
Name: Gliquidone sodium
CAS#: 62783-47-5 (sodium)
Chemical Formula: C27H32N3NaO6S
Exact Mass: 0.0000
Molecular Weight: 549.62
Elemental Analysis: C, 59.00; H, 5.87; N, 7.65; Na, 4.18; O, 17.47; S, 5.83
The following data is based on the product molecular weight 549.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
