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MedKoo Cat#: 584706 | Name: Mefenidil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mefenidil is a cerebral vasodilator agent.

Chemical Structure

Mefenidil
Mefenidil
CAS#58261-91-9 (free base)

Theoretical Analysis

MedKoo Cat#: 584706

Name: Mefenidil

CAS#: 58261-91-9 (free base)

Chemical Formula: C12H11N3

Exact Mass: 197.0953

Molecular Weight: 197.24

Elemental Analysis: C, 73.07; H, 5.62; N, 21.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
58261-91-9 (free base) 83153-38-2 (fumarate)
Synonym
Mefenidil; McN-2378; McN 2378
IUPAC/Chemical Name
1H-Imidazole-4-acetonitrile, 5-methyl-2-phenyl-
InChi Key
OTRQRKIYHATFKM-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H11N3/c1-9-11(7-8-13)15-12(14-9)10-5-3-2-4-6-10/h2-6H,7H2,1H3,(H,14,15)
SMILES Code
N#CCC1=C(C)NC(C2=CC=CC=C2)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 197.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Koehler RC, Wilson DA, Rogers MC, Traystman RJ. Effect of mefenidil on cerebral and peripheral hemodynamics in dogs. J Pharmacol Exp Ther. 1985 May;233(2):327-32. PubMed PMID: 3999024. 2: Flaim SF, Stranieri MT, Mathiasen JR, Brannan MD. Effects of mefenidil hydrochloride on cerebral blood flow in conscious and anesthetized rat. Pharmacology. 1986;33(3):167-80. PubMed PMID: 3749246.