LY2066948 | CAS#648904-56-7

MedKoo Cat#: 530252 | Name: LY2066948

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY2066948 is a selective estrogen receptor modulator.

Chemical Structure

LY2066948

CAS#648904-56-7

Theoretical Analysis

MedKoo Cat#: 530252

Name: LY2066948

CAS#: 648904-56-7

Chemical Formula: C30H31NO5S

Exact Mass: 517.1923

Molecular Weight: 517.64

Elemental Analysis: C, 69.61; H, 6.04; N, 2.71; O, 15.45; S, 6.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LY2066948

IUPAC/Chemical Name

6-(4-(Methanesulfonyl)phenyl)-5-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-ol

InChi Key

NJVFOFMHUJJIMB-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H31NO5S/c1-37(33,34)27-13-5-22(6-14-27)28-15-7-23-21-24(32)8-16-29(23)30(28)36-26-11-9-25(10-12-26)35-20-19-31-17-3-2-4-18-31/h5-16,21,32H,2-4,17-20H2,1H3

SMILES Code

OC1=CC=C2C(OC3=CC=C(OCCN4CCCCC4)C=C3)=C(C5=CC=C(S(=O)(C)=O)C=C5)C=CC2=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 517.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gherezghiher TB, Michalsen B, Chandrasena RE, Qin Z, Sohn J, Thatcher GR, Bolton JL. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. Chem Biol Interact. 2012 Mar 5;196(1-2):1-10. doi: 10.1016/j.cbi.2012.01.004. Epub 2012 Jan 28. PubMed PMID: 22290292; PubMed Central PMCID: PMC3319273. 2: Harris HA, Chennathukuzhi VM, Zhang X, Mekonnen B, Jelinsky SA, Schelling SH, Patel VS, Huselton C, Negahban A, Azam F, Winneker RC. Development of an early biomarker for the ovarian liability of selective estrogen receptor modulators in rats. J Steroid Biochem Mol Biol. 2008 Nov;112(1-3):40-6. doi: 10.1016/j.jsbmb.2008.08.008. Epub 2008 Sep 4. PubMed PMID: 18824103. 3: Rudmann DG, Cohen IR, Robbins MR, Coutant DE, Henck JW. Androgen dependent mammary gland virilism in rats given the selective estrogen receptor modulator LY2066948 hydrochloride. Toxicol Pathol. 2005;33(6):711-9. PubMed PMID: 16263696. 4: Hummel CW, Geiser AG, Bryant HU, Cohen IR, Dally RD, Fong KC, Frank SA, Hinklin R, Jones SA, Lewis G, McCann DJ, Rudmann DG, Shepherd TA, Tian H, Wallace OB, Wang M, Wang Y, Dodge JA. A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats. J Med Chem. 2005 Nov 3;48(22):6772-5. PubMed PMID: 16250633. 5: Geiser AG, Hummel CW, Draper MW, Henck JW, Cohen IR, Rudmann DG, Donnelly KB, Adrian MD, Shepherd TA, Wallace OB, McCann DJ, Oldham SW, Bryant HU, Sato M, Dodge JA. A new selective estrogen receptor modulator with potent uterine antagonist activity, agonist activity in bone, and minimal ovarian stimulation. Endocrinology. 2005 Oct;146(10):4524-35. Epub 2005 Jul 7. PubMed PMID: 16002528.