RSU 1131 | CAS#88876-89-5 | nitroimidazole-aziridine

MedKoo Cat#: 461500 | Name: RSU 1131

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RSU 1131 is a nitroimidazole-aziridine.

Chemical Structure

RSU 1131

CAS#88876-89-5

Theoretical Analysis

MedKoo Cat#: 461500

Name: RSU 1131

CAS#: 88876-89-5

Chemical Formula: C9H14N4O3

Exact Mass: 226.1066

Molecular Weight: 226.23

Elemental Analysis: C, 47.78; H, 6.24; N, 24.77; O, 21.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RSU 1131; RSU1131; RSU-1131;

IUPAC/Chemical Name

1-(2-methylaziridin-1-yl)-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol

InChi Key

AFLZZBWHQVDQKY-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H14N4O3/c1-7-4-12(7)6-8(14)5-11-3-2-10-9(11)13(15)16/h2-3,7-8,14H,4-6H2,1H3

SMILES Code

OC(CN1C(C)C1)CN2C=CN=C2[N+]([O-])=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 226.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: O'Neill P, McNeil SS, Jenkins TC. Induction of DNA crosslinks in vitro upon reduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131. Biochem Pharmacol. 1987 Jun 1;36(11):1787-92. PubMed PMID: 3579973. 2: Jenner TJ, Sapora O, O'Neill P, Fielden EM. Enhancement of DNA damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131. Biochem Pharmacol. 1988 Oct 15;37(20):3837-42. PubMed PMID: 3190731. 3: Sapora O, Paone A, Maggi A, Jenner TJ, O'Neill P. Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione. Biochem Pharmacol. 1992 Oct 6;44(7):1341-7. PubMed PMID: 1417957. 4: Walling J, Stratford IJ, Adams GE, Stephens MA. Dual-function radiation sensitizers and bioreductive drugs: factors affecting cellular uptake and sensitizing efficiency in analogues of RSU 1069. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Apr;53(4):641-9. PubMed PMID: 3258298.