RS-93522 is a calcium channel antagonist potentially for the treatment of hypertension. RS-93522 had the additional property of inhibiting phosphodiesterase activity in myocardial homogenates with IC50 = 1.6 x 10(-5)M; the potency and efficacy of phosphodiesterase inhibition was similar to that for milrinone in the same system. As expected of Ca channel antagonists, it has a negative inotropic effect on cultured myocardial cells. RS-93522 also has phosphodiesterase inhibitory activity that possibly may potentiate vasodilatation and ameliorate, in part, negative inotropic effects.
MedKoo Cat#: 528522
Name: RS-93522
CAS#: 104060-12-0
Chemical Formula: C27H30N2O9
Exact Mass: 526.1951
Molecular Weight: 526.54
Elemental Analysis: C, 61.59; H, 5.74; N, 5.32; O, 27.35
The following data is based on the product molecular weight 526.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
