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MedKoo Cat#: 529179 | Name: LY 289612

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 289612 is a bioactive chemical.

Chemical Structure

LY 289612
LY 289612
CAS#148314-61-8

Theoretical Analysis

MedKoo Cat#: 529179

Name: LY 289612

CAS#: 148314-61-8

Chemical Formula: C35H40N5O5

Exact Mass: 610.3029

Molecular Weight: 610.74

Elemental Analysis: C, 68.83; H, 6.60; N, 11.47; O, 13.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LY 289612
IUPAC/Chemical Name
N^1-(3-(2-(((1,1-Dimethylethyl)amino)carbonyl)phenyl)-2(R)-hydroxy-1(S)-(phenylmethyl)propyl)-2(S)-((2-quinolinylcarbonyl)amino)butanediamide
InChi Key
MYLHEJUNFLUBPV-BHBYDHKZSA-N
InChi Code
InChI=1S/C35H40N5O5/c1-34(2,3)38-32(43)26-15-9-7-14-25(26)22-30(41)27(21-23-11-5-4-6-12-23)35(45,20-19-31(36)42)40-39-33(44)29-18-17-24-13-8-10-16-28(24)37-29/h4-18,27,30,41H,19-22H2,1-3H3,(H2,36,42)(H,38,43)(H,39,44)(H,40,45)/t27-,30+/m0/s1
SMILES Code
O=C(NNC(C1=NC2=CC=CC=C2C=C1)=O)([C@@H](CC3=CC=CC=C3)[C@H](O)CC4=CC=CC=C4C(NC(C)(C)C)=O)CCC(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 610.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rosso C, Blanc R, Ly J, Samson Y, Lehéricy S, Gory B, Marnat G, Mazighi M, Consoli A, Labreuche J, Saleme S, Costalat V, Bracard S, Desal H, Piotin M, Lapergue B; ASTER Trial and Pitié-Salpêtrière Investigators. Impact of infarct location on functional outcome following endovascular therapy for stroke. J Neurol Neurosurg Psychiatry. 2018 Nov 13. pii: jnnp-2018-318869. doi: 10.1136/jnnp-2018-318869. [Epub ahead of print] PubMed PMID: 30425161. 2: Tong J, Zhang H, Yang D, Zhang Y, Xiong B, Jiang L. Illumina sequencing analysis of the ruminal microbiota in high-yield and low-yield lactating dairy cows. PLoS One. 2018 Nov 13;13(11):e0198225. doi: 10.1371/journal.pone.0198225. eCollection 2018. PubMed PMID: 30423588. 3: Huang W, Zhang X, Li A, Xie L, Miao X. Genome-Wide Analysis of mRNAs and lncRNAs of Intramuscular Fat Related to Lipid Metabolism in Two Pig Breeds. Cell Physiol Biochem. 2018 Nov 13;50(6):2406-2422. doi: 10.1159/000495101. [Epub ahead of print] PubMed PMID: 30423578. 4: Wang Y, Deng M, Chen Q, Li Y, Guo X, Shi P, He L, Xie S, Yu L, Zhang H, Xu B. Apatinib exerts anti-tumor activity to non-Hodgkin lymphoma by inhibition of the Ras pathway. Eur J Pharmacol. 2018 Nov 10. pii: S0014-2999(18)30666-6. doi: 10.1016/j.ejphar.2018.11.012. [Epub ahead of print] PubMed PMID: 30423319. 5: Le T, Ly VT, Thu NTM, Nguyen A, Thanh NT, Vinh Chau NV, Thwaites G, Perfect J, Kolamunnage-Dona R, Hope W. Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei. Antimicrob Agents Chemother. 2018 Nov 12. pii: AAC.01739-18. doi: 10.1128/AAC.01739-18. [Epub ahead of print] PubMed PMID: 30420478. 6: Hurbánková M, Volkovová K, Wimmerová S, Henčeková D, Moricová Š. Respiratory toxicity of TiO(2) nanoparticles after intravenous instillation: an experimental study. Cent Eur J Public Health. 2018 Sep;26(3):177-182. doi: 10.21101/cejph.a5222. PubMed PMID: 30419618. 7: Babut M, Mourier B, Desmet M, Simonnet-Laprade C, Labadie P, Budzinski H, De Alencastro LF, Tu TA, Strady E, Gratiot N. Where has the pollution gone? A survey of organic contaminants in Ho Chi Minh city / Saigon River (Vietnam) bed sediments. Chemosphere. 2018 Nov 2;217:261-269. doi: 10.1016/j.chemosphere.2018.11.008. [Epub ahead of print] PubMed PMID: 30419380. 8: Kilari RS, Bashir AIJ, Devitt A, Perry CJ, Safrany ST, Nicholl ID. The cytotoxicity and synergistic potential of aspirin and aspirin analogues towards oesophageal and colorectal cancer. Curr Clin Pharmacol. 2018 Nov 12. doi: 10.2174/1574884713666181112141151. [Epub ahead of print] PubMed PMID: 30417794. 9: Ly P, Hayes DK, Yamashiroya V, Turnure MM, Iwaishi LK. Knowledge and Attitudes Towards Fluoride Supplementation: A Survey of Pediatric Medical and Dental Providers in the State of Hawai'i. Hawaii J Med Public Health. 2018 Nov;77(11):275-282. PubMed PMID: 30416870; PubMed Central PMCID: PMC6218681. 10: Zhang H, Wei Q, Gao Z, Ma C, Yang Z, Zhao H, Liu C, Liu J, Zhao X, Ma B. G protein-coupled receptor 30 mediates meiosis resumption and gap junction communications downregulation in goat cumulus-oocyte complexes by 17β-estradiol. J Steroid Biochem Mol Biol. 2018 Nov 8. pii: S0960-0760(18)30471-0. doi: 10.1016/j.jsbmb.2018.11.001. [Epub ahead of print] PubMed PMID: 30414946. 11: Zhu H, Zhang L, Wu Y, Dong B, Guo W, Wang M, Yang L, Fan X, Tang Y, Liu N, Lei X, Wu H. T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1. Elife. 2018 Nov 9;7. pii: e38314. doi: 10.7554/eLife.38314. [Epub ahead of print] PubMed PMID: 30412053. 12: Ly A, Longuespée R, Casadonte R, Wandernoth P, Schwamborn K, Bollwein C, Marsching C, Kriegsmann K, Hopf C, Weichert W, Kriegsmann J, Schirmacher P, Kriegsmann M, Deininger SO. Site-to-Site Reproducibility and Spatial Resolution in MALDI-MSI of Peptides from Formalin-Fixed Paraffin-Embedded Samples. Proteomics Clin Appl. 2018 Nov 8:e1800029. doi: 10.1002/prca.201800029. [Epub ahead of print] PubMed PMID: 30408343. 13: Liu B, Maekawa T, Yoshida K, Ly NH, Inoue K, Hasegawa A, Chatton B, Ogura A, Ishii S. Telomere shortening by transgenerational transmission of TNF-α-induced TERRA via ATF7. Nucleic Acids Res. 2018 Nov 8. doi: 10.1093/nar/gky1149. [Epub ahead of print] PubMed PMID: 30407559. 14: Balsam P, Tymińska A, Ozierański K, Zaleska M, Żukowska K, Szepietowska K, Maciejewski K, Peller M, Grabowski M, Lodziński P, Kołtowski Ł, Praska-Ogińska A, Zaboyska I, Bednarski J, Filipiak KJ, Opolski G. Randomized controlled clinical trials versus real-life atrial fibrillation patients treated with oral anticoagulants. Do we treat the same patients? Cardiol J. 2018 Nov 8. doi: 10.5603/CJ.a2018.0135. [Epub ahead of print] PubMed PMID: 30406937. 15: Jones R, Krishnan A, Zeybel GL, Dookun E, Pearson JP, Simpson AJ, Griffin SM, Ward C, Forrest IA. Reflux in idiopathic pulmonary fibrosis: treatment informed by an integrated approach. ERJ Open Res. 2018 Nov 5;4(4). pii: 00051-2018. doi: 10.1183/23120541.00051-2018. eCollection 2018 Oct. PubMed PMID: 30406124; PubMed Central PMCID: PMC6215913. 16: Zhang J, Cui N, Long Y, Wang H, Han W, Li Y, Xiao M. Prospective evaluation of lymphocyte subtyping for the diagnosis of invasive candidiasis in non-neutropenic critically ill patients. Int J Infect Dis. 2018 Nov 3. pii: S1201-9712(18)34576-4. doi: 10.1016/j.ijid.2018.10.028. [Epub ahead of print] PubMed PMID: 30399447. 17: Benonisson H, Sow HS, Breukel C, Claassens J, Brouwers C, Linssen MM, Fransen MF, Sluijter M, Ossendorp F, van Hall T, Verbeek JS. High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy. J Immunol. 2018 Nov 5. pii: ji1800700. doi: 10.4049/jimmunol.1800700. [Epub ahead of print] PubMed PMID: 30397036. 18: Naylor MR, Ly AM, Handford MJ, Ramos DP, Pye CR, Furukawa A, Klein V, Noland RP, Edmondson Q, Turmon AC, Hewitt WM, Schwochert J, Townsend CE, Kelly CN, Blanco MJ, Lokey RS. Lipophilic Permeability Efficiency (LPE) reconciles the opposing roles of lipophilicity in membrane permeability and aqueous solubility. J Med Chem. 2018 Nov 5. doi: 10.1021/acs.jmedchem.8b01259. [Epub ahead of print] PubMed PMID: 30395703. 19: Kittanakom S, Ly V, Arnoldo A, Beattie A, Kavsak PA. Pre-analytical variables affecting discordant results on repeat sample testing for cardiac troponin I. Clin Biochem. 2018 Oct 27. pii: S0009-9120(18)30986-X. doi: 10.1016/j.clinbiochem.2018.10.014. [Epub ahead of print] PubMed PMID: 30393000. 20: Ly S, Boulagnon-Rombi C. An atypical pituitary incidentaloma. Neurochirurgie. 2018 Nov 1. pii: S0028-3770(18)30333-3. doi: 10.1016/j.neuchi.2018.10.002. [Epub ahead of print] PubMed PMID: 30392970.

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