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MedKoo Cat#: 540125 | Name: Ethacridine lactate monohydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ethacridine lactate monohydrate is an acridine derivative and DNA intercalator used as an antiseptic It increases levels of prostaglandin E, decreases excretion of estriol, and may induce fetal death in pregnant females.

Chemical Structure

Ethacridine lactate monohydrate
Ethacridine lactate monohydrate
CAS#6402-23-9 (lactate monohydrate)

Theoretical Analysis

MedKoo Cat#: 540125

Name: Ethacridine lactate monohydrate

CAS#: 6402-23-9 (lactate monohydrate)

Chemical Formula: C18H23N3O5

Exact Mass: 361.1638

Molecular Weight: 361.40

Elemental Analysis: C, 59.82; H, 6.42; N, 11.63; O, 22.13

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 450.00 2 Weeks
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Related CAS #
442-16-0 (free base) 1837-57-6 (lactate) 6402-23-9 (lactate monohydrate)
Synonym
Rivanol monohydrate; Ethacridine lactate hydrate; Acrinol hydrate; Acrinol Monohydrate; Acrolactin;
IUPAC/Chemical Name
7-ethoxyacridine-3,9-diamine 2-hydroxypropanoate hydrate
InChi Key
NYEPHMYJRNWPLA-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H15N3O.C3H6O3.H2O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6;/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6);1H2
SMILES Code
CC(O)C(O)=O.NC1=CC2=NC3=CC=C(OCC)C=C3C(N)=C2C=C1.[H]O[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient.
In vitro activity:
Ethacridine suppressed cell growth and clonogenic ability of thyroid cancer cells in a time- and dose-dependent manner (p<0.001). Reference: bioRxiv [Preprint]. 2020 Oct 28:2020.10.28.359042. https://pubmed.ncbi.nlm.nih.gov/31366493/
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 86.0 237.96
Ethanol 1.0 2.77
Water 3.5 9.68
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 361.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Li X, Lidsky P, Xiao Y, Wu CT, GarciaKnight M, Yang J, Nakayama T, Nayak JV, Jackson PK, Andino R, Shu X. Ethacridine inhibits SARS-CoV-2 by inactivating viral particles in cellular models. bioRxiv [Preprint]. 2020 Oct 28:2020.10.28.359042. doi: 10.1101/2020.10.28.359042. PMID: 33140048; PMCID: PMC7605555. 2. Huang TS, Lee JJ, Li YS, Cheng SP. Ethacridine Induces Apoptosis and Differentiation in Thyroid Cancer Cells In Vitro. Anticancer Res. 2019 Aug;39(8):4095-4100. doi: 10.21873/anticanres.13567. PMID: 31366493.
In vitro protocol:
1. Li X, Lidsky P, Xiao Y, Wu CT, GarciaKnight M, Yang J, Nakayama T, Nayak JV, Jackson PK, Andino R, Shu X. Ethacridine inhibits SARS-CoV-2 by inactivating viral particles in cellular models. bioRxiv [Preprint]. 2020 Oct 28:2020.10.28.359042. doi: 10.1101/2020.10.28.359042. PMID: 33140048; PMCID: PMC7605555. 2. Huang TS, Lee JJ, Li YS, Cheng SP. Ethacridine Induces Apoptosis and Differentiation in Thyroid Cancer Cells In Vitro. Anticancer Res. 2019 Aug;39(8):4095-4100. doi: 10.21873/anticanres.13567. PMID: 31366493.
In vivo protocol:
TBD