SW15 | HSP27 Cross Linker

MedKoo Cat#: 564256 | Name: SW15

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SW15 is a potent HSP27 cross linker which alters dimeric HSP27 and yields sensitization in human lung cancer cells when combined with HSP90 inhibitors or standard anticancer modalities such as irradiation and cytotoxic anticancer drugs.

Chemical Structure

SW15

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564256

Name: SW15

CAS#: NONE

Chemical Formula: C20H16O4S2

Exact Mass: 384.0490

Molecular Weight: 384.46

Elemental Analysis: C, 62.48; H, 4.19; O, 16.65; S, 16.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SW-15; SW 15; SW15

IUPAC/Chemical Name

1,3-Bis(thiiran-2-ylmethoxy)-9H-xanthen-9-one

InChi Key

HEJFBUFZDGKAEO-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H16O4S2/c21-19-14-3-1-2-4-15(14)20(22)18-16(19)5-11(23-7-12-9-25-12)6-17(18)24-8-13-10-26-13/h1-6,12-13H,7-10H2

SMILES Code

O=C1C2=C(C(C3=C1C=CC=C3)=O)C=C(OCC4SC4)C=C2OCC5SC5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 384.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jans DA, Moll T, Nasmyth K, Jans P. Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cells. J Biol Chem. 1995 Jul 21;270(29):17064-7. PubMed PMID: 7615496. 2: Stillman DJ, Dorland S, Yu Y. Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator. Genetics. 1994 Mar;136(3):781-8. PubMed PMID: 8005433; PubMed Central PMCID: PMC1205884. 3: Lydall D, Ammerer G, Nasmyth K. A new role for MCM1 in yeast: cell cycle regulation of SW15 transcription. Genes Dev. 1991 Dec;5(12B):2405-19. PubMed PMID: 1752436. 4: Nasmyth K, Adolf G, Lydall D, Seddon A. The identification of a second cell cycle control on the HO promoter in yeast: cell cycle regulation of SW15 nuclear entry. Cell. 1990 Aug 24;62(4):631-47. PubMed PMID: 2167175. 5: Neuhaus D, Nakaseko Y, Nagai K, Klug A. Sequence-specific [1H]NMR resonance assignments and secondary structure identification for 1- and 2-zinc finger constructs from SW15. A hydrophobic core involving four invariant residues. FEBS Lett. 1990 Mar 26;262(2):179-84. PubMed PMID: 2110530. 6: Nasmyth K, Seddon A, Ammerer G. Cell cycle regulation of SW15 is required for mother-cell-specific HO transcription in yeast. Cell. 1987 May 22;49(4):549-58. PubMed PMID: 3552251.