Synonym
EXP-561 monohydrate
IUPAC/Chemical Name
4-Phenylbicyclo(2.2.2)octan-1-amine hydrochloride monohydrate
InChi Key
NLXFYKZUFJZKCP-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H19N.ClH.H2O/c15-14-9-6-13(7-10-14,8-11-14)12-4-2-1-3-5-12;;/h1-5H,6-11,15H2;1H;1H2
SMILES Code
NC1(CC2)CCC2(C3=CC=CC=C3)CC1.[H]Cl.[H]O[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
255.79
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Maj J, Skuza G, Sowińska H, Nowak G. Pharmacological properties of EXP 561, a potential antidepressant drug. J Neural Transm. 1987;70(1-2):81-97. doi: 10.1007/BF01252511. PMID: 2822850.
2: Fuller RW, Snoddy HD. Effects of pre- and post-treatment with EXP 561 on the amine-depleting effects of p-chloroamphetamine and 6-hydroxydopamine in rats. Res Commun Chem Pathol Pharmacol. 1978 Sep;21(3):457-65. PMID: 705024.
3: Gershon S, Hekimian LJ, Floyd A. Non-correlation of preclinical-clinical evaluation of a prosposed anti-depressant 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561). Arzneimittelforschung. 1968 Feb;18(2):243-5. PMID: 5695389.
4: Koe BK. Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain. J Pharmacol Exp Ther. 1976 Dec;199(3):649-61. PMID: 994022.
5: Lehmann HE, Ban TA, Debow SL. A clinical-pharmacological study with EXP 561. Curr Ther Res Clin Exp. 1967 Jun;9(6):306-8. PMID: 4963065.
6: Robertson DW, Jones ND, Swartzendruber JK, Yang KS, Wong DT. Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor. J Med Chem. 1988 Jan;31(1):185-9. doi: 10.1021/jm00396a030. PMID: 3257267.
7: Fuller RW, Robertson DW, Hemrick-Luecke SK. Comparison of the effects of two 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs, 1-methyl-4-(2-thienyl)-1,2,3,6-tetrahydropyridine and 1-methyl-4-(3-thienyl)-1,2,3,6-tetrahydropyridine, on monoamine oxidase in vitro and on dopamine in mouse brain. J Pharmacol Exp Ther. 1987 Feb;240(2):415-20. PMID: 3100775.
8: Fuller RW, Hemrick-Luecke SK, Perry KW. Deprenyl antagonizes acute lethality of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. J Pharmacol Exp Ther. 1988 Nov;247(2):531-5. PMID: 3141609.
9: Fuller RW, Hemrick-Luecke SK, Robertson DW. Comparison of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) effects on mouse heart norepinephrine. Biochem Pharmacol. 1988 Sep 1;37(17):3343-7. doi: 10.1016/0006-2952(88)90648-x. PMID: 3135812.
10: Fuller RW, Snoddy HD, Molloy BB. Blockade of amine depletion by nisoxetine in comparison to other uptake inhibitors. Psychopharmacol Commun. 1975;1(5):455-64. PMID: 1228825.
