MedKoo Cat#: 464254 | Name: Gancidin W

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Gancidin W is a diketopiperazine compound isolated from the endophytic Streptomyces strain SUK10, derived from the bark of the Shorea ovalis tree.Gancidin W demonstrated significant antimalarial activity in vivo against Plasmodium berghei PZZ1/100. Gancidin W exhibits potent antimalarial properties with minimal toxicity, positioning it as a promising candidate for antimalarial therapy. Gancidin W has also demonstrated broad-spectrum antibacterial activity.

Chemical Structure

Gancidin W
Gancidin W
CAS#2873-36-1

Theoretical Analysis

MedKoo Cat#: 464254

Name: Gancidin W

CAS#: 2873-36-1

Chemical Formula: C11H18N2O2

Exact Mass: 210.1368

Molecular Weight: 210.28

Elemental Analysis: C, 62.83; H, 8.63; N, 13.32; O, 15.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
L-Leucyl-L-proline lactam; L-Leucyl-L-prolyl lactam; cis-Cyclo(L-Leu-L-Pro); Cyclo(L-Leu-L-Pro); Cyclo(L-leucyl-L-prolyl); Cyclo(L-Pro-L-Leu); Cyclo(L-prolyl-L-leucyl); Cyclo(Leu-Pro); Cyclo(Pro-Leu); Cyclo(proline-leucine); Cyclo-L-prolyl-L-leucine; Gancidin W; Maculosin 6;
IUPAC/Chemical Name
(3S,8aS)-3-isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
InChi Key
SZJNCZMRZAUNQT-IUCAKERBSA-N
InChi Code
InChI=1S/C11H18N2O2/c1-7(2)6-8-11(15)13-5-3-4-9(13)10(14)12-8/h7-9H,3-6H2,1-2H3,(H,12,14)/t8-,9-/m0/s1
SMILES Code
O=C1N2[C@](C(=O)N[C@H]1CC(C)C)(CCC2)[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 210.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ahmad SJ, Abdul Rahim MBH, Baharum SN, Baba MS, Zin NM. Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. J Trop Med. 2017;2017:2189814. doi: 10.1155/2017/2189814. Epub 2017 Oct 16. PMID: 29123551; PMCID: PMC5662797. 2: Zin NM, Baba MS, Zainal-Abidin AH, Latip J, Mazlan NW, Edrada-Ebel R. Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10. Drug Des Devel Ther. 2017 Feb 8;11:351-363. doi: 10.2147/DDDT.S121283. PMID: 28223778; PMCID: PMC5308589. 3: Ghosh S, Kuisiene N, Cheeptham N. The cave microbiome as a source for drug discovery: Reality or pipe dream? Biochem Pharmacol. 2017 Jun 15;134:18-34. doi: 10.1016/j.bcp.2016.11.018. Epub 2016 Nov 17. PMID: 27867014.