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MedKoo Cat#: 593019 | Name: Atizoram
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Atizoram, or CP-80,633, is a cyclic nucleotide phosphodiesterase (PDE4) inhibitor, has been shown to augment intracellular cAMP levels and to inhibit TNFalpha release from human monocytes in vitro.

Chemical Structure

Atizoram
Atizoram
CAS#135637-46-6

Theoretical Analysis

MedKoo Cat#: 593019

Name: Atizoram

CAS#: 135637-46-6

Chemical Formula: C18H24N2O3

Exact Mass: 316.1787

Molecular Weight: 316.40

Elemental Analysis: CC, 68.33; H, 7.65; N, 8.85; O, 15.17

Price and Availability

Size Price Availability Quantity
1mg USD 250.00 2 Weeks
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Related CAS #
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Synonym
Atizoram; CP 80,633; CP-80,633; CP80,633; CP 80633; CP80633; CP-80633
IUPAC/Chemical Name
Tetrahydro-5-(4-methoxy-3-((1S,2S,4R)-2-norbomyloxy)phenyl)-2(1H)-pyrimidinone
InChi Key
LITNEAPWQHVPOK-FFSVYQOJSA-N
InChi Code
InChI=1S/C18H24N2O3/c1-22-15-5-4-12(14-9-19-18(21)20-10-14)8-17(15)23-16-7-11-2-3-13(16)6-11/h4-5,8,11,13-14,16H,2-3,6-7,9-10H2,1H3,(H2,19,20,21)/t11-,13+,16+/m1/s1
SMILES Code
COc1c(O[C@H]2C[C@@H]3CC[C@H]2C3)cc(C4CNC(NC4)=O)cc1
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 316.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Turner CR, Cohan VL, Cheng JB, Showell HJ, Pazoles CJ, Watson JW. The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4. J Pharmacol Exp Ther. 1996 Sep;278(3):1349-55. PMID: 8819522. 2: Cheng JB, Watson JW, Pazoles CJ, Eskra JD, Griffiths RJ, Cohan VL, Turner CR, Showell HJ, Pettipher ER. The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor- alpha (TNFalpha) production in mice: effect of adrenalectomy. J Pharmacol Exp Ther. 1997 Feb;280(2):621-6. PMID: 9023272. 3: Wright KF, Turner CR, Jayasinghe-Beck R, Cohen VL, Cheng JB, Watson JW. Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitor. Can J Physiol Pharmacol. 1997 Aug;75(8):1001-8. PMID: 9360015. 4: Mezzani A, Corrà U, Giordano A, Colombo S, Psaroudaki M, Giannuzzi P. Upper intensity limit for prolonged aerobic exercise in chronic heart failure. Med Sci Sports Exerc. 2010 Apr;42(4):633-9. doi: 10.1249/MSS.0b013e3181bdc69d. PMID: 19952837. 5: Hao L, Wang LS, Liu Y, Wang T, Guo HL, Pan J, Wang D, Bi YW, Ji JT, Xin L, Du TT, Lin JH, Zhang D, Zeng XP, Zou WB, Chen H, Xie T, Li BR, Liao Z, Cong ZJ, Xu ZL, Li ZS, Hu LH. The different course of alcoholic and idiopathic chronic pancreatitis: A long-term study of 2,037 patients. PLoS One. 2018 Jun 8;13(6):e0198365. doi: 10.1371/journal.pone.0198365. PMID: 29883461; PMCID: PMC5993321. 6: Das NG, Huque KS, Amanullah SM, Dharmapuri S, Makkar HPS. Study of chemical composition and nutritional values of vegetable wastes in Bangladesh. Vet Anim Sci. 2018 Mar 2;5:31-37. doi: 10.1016/j.vas.2018.02.003. PMID: 32734043; PMCID: PMC7386774. 7: Cohan VL, Showell HJ, Fisher DA, Pazoles CJ, Watson JW, Turner CR, Cheng JB. In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633. J Pharmacol Exp Ther. 1996 Sep;278(3):1356-61. PMID: 8819523. 8: Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower CR, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study. BMC Nephrol. 2012 Nov 14;13:148. doi: 10.1186/1471-2369-13-148. PMID: 23151275; PMCID: PMC3534523. 9: Nielsen HL, Engberg J, Ejlertsen T, Nielsen H. Evaluation of fecal calprotectin in Campylobacter concisus and Campylobacter jejuni/coli gastroenteritis. Scand J Gastroenterol. 2013 May;48(5):633-5. doi: 10.3109/00365521.2013.775329. Epub 2013 Mar 1. PMID: 23448294. 10: Patrocinio TA, Fernandes CAC, Macedo GC, Silva ADD, Barbosa NRR, Quintao CCR, Ribeiro MEDS, Camargo LSA. RA33, an analogue of resveratrol, improves the development of in vitro-fertilized bovine embryos. Zygote. 2022 Dec;30(6):891-894. doi: 10.1017/S0967199422000430. Epub 2022 Sep 23. PMID: 36148879. 11: Tamiya M, Tamiya A, Yamadori T, Nakao K, Asami K, Yasue T, Otsuka T, Shiroyama T, Morishita N, Suzuki H, Okamoto N, Okishio K, Kawaguchi T, Atagi S, Kawase I, Hirashima T. Phase2 study of bevacizumab with carboplatin-paclitaxel for non-small cell lung cancer with malignant pleural effusion. Med Oncol. 2013;30(3):676. doi: 10.1007/s12032-013-0676-7. Epub 2013 Aug 8. PMID: 23925664. 12: Zhao X, Luo X, Bazuin CG, Masson JF. In Situ Growth of AuNPs on Glass Nanofibers for SERS Sensors. ACS Appl Mater Interfaces. 2020 Dec 9;12(49):55349-55361. doi: 10.1021/acsami.0c15311. Epub 2020 Nov 25. PMID: 33237739. 13: Bettuzzi T, Bachelez H, Beylot-Barry M, Arlégui H, Paul C, Viguier M, Mahé E, Beneton N, Jullien D, Richard MA, Joly P, Tubach F, Dupuy A, Sbidian E, Chosidow O; PsoBioTeq study group. Evolution of Drug Survival with Biological Agents and Apremilast Between 2012 and 2018 in Patients with Psoriasis from the PsoBioTeq Cohort. Acta Derm Venereol. 2022 Mar 8;102:adv00665. doi: 10.2340/actadv.v101.566. PMID: 34806759; PMCID: PMC9631244. 14: Eid MM, Saleh MS, Allam NM, Elsherbini DM, Abdelbasset WK, Eladl HM. Narrow Band Ultraviolet B Versus Red Light-Emitting Diodes in the Treatment of Facial Acne Vulgaris: A Randomized Controlled Trial. Photobiomodul Photomed Laser Surg. 2021 Jun;39(6):418-424. doi: 10.1089/photob.2020.4988. Epub 2021 May 20. PMID: 34015228. 15: Yasui Y, Hannon CP, Fraser EJ, Ackermann J, Boakye L, Ross KA, Duke GL, Shimozono Y, Kennedy JG. Lesion Size Measured on MRI Does Not Accurately Reflect Arthroscopic Measurement in Talar Osteochondral Lesions. Orthop J Sports Med. 2019 Feb 12;7(2):2325967118825261. doi: 10.1177/2325967118825261. PMID: 30800691; PMCID: PMC6378450. 16: Malhotra D, Boyle SH, Gifford EJ, Sullivan BA, Nguyen Wenker TH, Abs ND, Ahmed ST, Upchurch J, Vahey J, Stafford C, Efird JT, Hunt SC, Bradford A, Sims KJ, Hauser ER, Helmer DA, Williams CD. Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder. Neurogastroenterol Motil. 2023 May;35(5):e14548. doi: 10.1111/nmo.14548. Epub 2023 Mar 21. PMID: 36942766. 17: Smith JE, Paton JF, Andrews PL. An arterially perfused decerebrate preparation of Suncus murinus (house musk shrew) for the study of emesis and swallowing. Exp Physiol. 2002 Sep;87(5):563-74. doi: 10.1113/eph8702424. PMID: 12481931. 18: Jackson DS, Banerjee S, Sirey JA, Pollari C, Solomonov N, Novitch R, Chalfin A, Wu Y, Alexopoulos GS. Two Interventions for PatientsWith Major Depression and Severe Chronic Obstructive Pulmonary Disease: Impact on Quality of Life. Am J Geriatr Psychiatry. 2019 May;27(5):502-511. doi: 10.1016/j.jagp.2018.12.004. Epub 2018 Dec 7. PMID: 30630702; PMCID: PMC6443466. 19: Abhilash RH, Chauhan S, Che MV, Ooi CC, Bakar RA, Lo RH. Quantitative Study on the Effect of Abnormalities on Respiration-Induced Kidney Movement. Ultrasound Med Biol. 2016 Jul;42(7):1681-8. doi: 10.1016/j.ultrasmedbio.2016.01.015. Epub 2016 Apr 25. PMID: 27126242. 20: Song YS, Park CM, Park SJ, Lee SM, Jeon YK, Goo JM. Volume and mass doubling times of persistent pulmonary subsolid nodules detected in patients without known malignancy. Radiology. 2014 Oct;273(1):276-84. doi: 10.1148/radiol.14132324. Epub 2014 Jun 14. PMID: 24927472.