MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 562971 | Name: Bozepinib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bozepinib is an antitumor agent. It acts by inducing PKR-mediated apoptosis and synergizing with IFN.

Chemical Structure

Bozepinib
Bozepinib
CAS#1207993-83-6

Theoretical Analysis

MedKoo Cat#: 562971

Name: Bozepinib

CAS#: 1207993-83-6

Chemical Formula: C20H14Cl2N6O5S

Exact Mass: 520.0123

Molecular Weight: 521.32

Elemental Analysis: C, 46.08; H, 2.71; Cl, 13.60; N, 16.12; O, 15.34; S, 6.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Bozepinib;
IUPAC/Chemical Name
3-(2,6-dichloro-9H-purin-9-yl)-1-((4-nitrophenyl)sulfonyl)-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepine
InChi Key
ADWZQHLAYGEBHB-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H14Cl2N6O5S/c21-18-17-19(25-20(22)24-18)26(11-23-17)16-9-27(15-4-2-1-3-12(15)10-33-16)34(31,32)14-7-5-13(6-8-14)28(29)30/h1-8,11,16H,9-10H2
SMILES Code
O=S(N1CC(N2C=NC3=C2N=C(Cl)N=C3Cl)OCC4=CC=CC=C41)(C5=CC=C([N+]([O-])=O)C=C5)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 521.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cruz-López O, Ramírez A, Navarro SA, García MA, Marchal JA, Campos JM, Conejo-García A. 1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds. Future Med Chem. 2017 Jul;9(11):1129-1140. doi: 10.4155/fmc-2017-0006. Epub 2017 Jul 19. PubMed PMID: 28722472. 2: Ramírez A, Boulaiz H, Morata-Tarifa C, Perán M, Jiménez G, Picon-Ruiz M, Agil A, Cruz-López O, Conejo-García A, Campos JM, Sánchez A, García MA, Marchal JA. HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. Oncotarget. 2014 Jun 15;5(11):3590-606. PubMed PMID: 24946763; PubMed Central PMCID: PMC4116505. 3: Marchal JA, Carrasco E, Ramirez A, Jiménez G, Olmedo C, Peran M, Agil A, Conejo-García A, Cruz-López O, Campos JM, García MÁ. Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNα triggering apoptosis, autophagy and senescence. Drug Des Devel Ther. 2013 Oct 29;7:1301-13. doi: 10.2147/DDDT.S51354. eCollection 2013. PubMed PMID: 24194639; PubMed Central PMCID: PMC3815003. 4: López-Cara LC, Conejo-García A, Marchal JA, Macchione G, Cruz-López O, Boulaiz H, García MA, Rodríguez-Serrano F, Ramírez A, Cativiela C, Jiménez AI, García-Ruiz JM, Choquesillo-Lazarte D, Aránega A, Campos JM. New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazep in-3-yl]-9H-purine. Eur J Med Chem. 2011 Jan;46(1):249-58. doi: 10.1016/j.ejmech.2010.11.011. Epub 2010 Dec 3. PubMed PMID: 21126804.