Synonym
Ditazole; Ditazol; S222; S 222; S-222
IUPAC/Chemical Name
2,2'-((4,5-Diphenyl-2-oxazolyl)imino)diethanol
InChi Key
UUCMDZWCRNZCOY-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N2O3/c22-13-11-21(12-14-23)19-20-17(15-7-3-1-4-8-15)18(24-19)16-9-5-2-6-10-16/h1-10,22-23H,11-14H2
SMILES Code
OCCN(CCO)C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
324.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Maurer H, Kleff I. On the metabolism of ditazole in man. Arzneimittelforschung. 1988 Dec;38(12):1843-5. PMID: 2907728.
2: Caprino L, Borrelli F, Falchetti R, Cafiero C, Gandolfo GM. Ditazole activity and its interaction with urokinase on experimental thrombosis. Haemostasis. 1977;6(5):310-7. doi: 10.1159/000214196. PMID: 23345.
3: De Gaetano G, Tonolli MC, Bertoni MP, Roncaglioni MC. Ditazole and platelets. I. Effect of ditazole on human platelet function in vitro. Haemostasis. 1977;6(2):127-36. doi: 10.1159/000214172. PMID: 16812.
4: De Gaetano G, Cavenaghi AE, Stella L. Ditazole and platelets. II. Effect of ditazole on in vivo platelet aggregation and bleeding time in rats. Haemostasis. 1977;6(3):190-6. doi: 10.1159/000214179. PMID: 18382.
5: de Gaetano G, Dal Bo L, Villa S, Mussini E, Marcucci F. Blood levels of ditazole and inhibition of platelet aggregation in man. Arzneimittelforschung. 1980;30(3):496-7. PMID: 6104495.
6: Mussoni L, Poggi A, Donati MB, de Gaetano G. Ditazole and platelets III. Effect of ditazole on tumor-cell induced thrombocytopenia and on bleeding time in mice. Haemostasis. 1977;6(4):260-5. doi: 10.1159/000214188. PMID: 21124.
7: Mussoni L, Poggi A, De Gaetano G, Donati MB. Effect of ditazole, an inhibitor of platelet aggregation, on a metastasizing tumour in mice. Br J Cancer. 1978 Jan;37(1):126-9. doi: 10.1038/bjc.1978.18. PMID: 23140; PMCID: PMC2009508.
8: Prisco D, Favilla S, Fortini A, Gensini GF. In vitro investigation on the antiaggregating activity of ditazole. Int J Clin Pharmacol Res. 1984;4(5):341-7. PMID: 6151552.
9: Marcucci F, Riva R, Gomeni R, Zavattini G, Lacombe PS, Mussini E. Pharmacokinetic studies on ditazole, a novel inhibitor of platelet aggregation. J Pharm Sci. 1978 May;67(5):705-6. doi: 10.1002/jps.2600670537. PMID: 25334.
10: Sim AK, McCraw AP, Caprino L, Antonetti F, Martelli F, Morelli L. The vascular protection of ditazole and its effect on arachidonic acid metabolism. Thromb Res. 1983 Dec 1;32(5):479-93. doi: 10.1016/0049-3848(83)90258-x. PMID: 6140774.
