SCH-538415 | CAS#637772-75-9

MedKoo Cat#: 407389 | Name: SCH-538415

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SCH-538415 is a novel acyl carrier protein synthase inhibitor from a microorganism. SCH-538415 exhibited inhibitory activity in the acyl carrier protein synthase (AcpS) assay with an IC(50) value of 4.19 microM and showed antibacterial activity against Staphylococcus aureus in the agar diffusion assay.

Chemical Structure

SCH-538415

CAS#637772-75-9

Theoretical Analysis

MedKoo Cat#: 407389

Name: SCH-538415

CAS#: 637772-75-9

Chemical Formula: C16H14N2O4

Exact Mass: 298.0954

Molecular Weight: 298.30

Elemental Analysis: C, 64.42; H, 4.73; N, 9.39; O, 21.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SCH-538415; SCH 538415; SCH 538415.

IUPAC/Chemical Name

1,4,6,9-tetramethyl-Pyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetrone

InChi Key

FUHFHTKNERQJIU-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H14N2O4/c1-7-5-9(19)17(3)13-11(7)15(21)12-8(2)6-10(20)18(4)14(12)16(13)22/h5-6H,1-4H3

SMILES Code

O=C1N(C)C2=C(C(C(C(C)=CC(N3C)=O)=C3C2=O)=O)C(C)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 298.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Bair JS, Palchaudhuri R, Hergenrother PJ. Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death. J Am Chem Soc. 2010 Apr 21;132(15):5469-78. doi: 10.1021/ja100610m. PubMed PMID: 20345134. 2: Pettit GR, Du J, Pettit RK, Richert LA, Hogan F, Mukku VJ, Hoard MS. Antineoplastic Agents. 554. The manitoba bacterium Streptomyces sp. J Nat Prod. 2006 May;69(5):804-6. PubMed PMID: 16724845. 3: Chu M, Mierzwa R, Xu L, Yang SW, He L, Patel M, Stafford J, Macinga D, Black T, Chan TM, Gullo V. Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3827-9. PubMed PMID: 14552789.