Synonym
LDN-05233; LDN05233; LDN 05233; Ac-QPKK(Ac)-AMC;
IUPAC/Chemical Name
(S)-N-((S)-1-(((S)-6-acetamido-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxohexan-2-yl)amino)-6-amino-1-oxohexan-2-yl)-1-(acetyl-L-glutaminyl)pyrrolidine-2-carboxamide
InChi Key
LHVYYJGFOAKRPP-DZUOILHNSA-N
InChi Code
InChI=1S/C36H52N8O9/c1-21-19-32(48)53-30-20-24(12-13-25(21)30)41-33(49)26(10-5-7-17-39-22(2)45)42-34(50)27(9-4-6-16-37)43-35(51)29-11-8-18-44(29)36(52)28(40-23(3)46)14-15-31(38)47/h12-13,19-20,26-29H,4-11,14-18,37H2,1-3H3,(H2,38,47)(H,39,45)(H,40,46)(H,41,49)(H,42,50)(H,43,51)/t26-,27-,28-,29-/m0/s1
SMILES Code
NCCCC[C@H](NC([C@@H]1CCCN1C([C@@H](NC(C)=O)CCC(N)=O)=O)=O)C(N[C@@H](CCCCNC(C)=O)C(NC2=CC=C3C(C)=CC(OC3=C2)=O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
A fluorogenic substrate for SIRT1, SIRT2, and SIRT3.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMF |
10.0 |
13.50 |
| DMSO |
15.0 |
20.25 |
| PBS (pH 7.2) |
10.0 |
13.50 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
740.86
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
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2: An J, Chen M, Hu N, Hu Y, Chen R, Lyu Y, Guo W, Li L, Liu Y. Carbon dots- based dual-emission ratiometric fluorescence sensor for dopamine detection. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Dec 15;243:118804. doi: 10.1016/j.saa.2020.118804. Epub 2020 Aug 10. PMID: 32799189.
3: Rodríguez-Enríquez F, Viña D, Uriarte E, Laguna R, Matos MJ. 7-Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation. ChemMedChem. 2021 Jan 8;16(1):179-186. doi: 10.1002/cmdc.202000454. Epub 2020 Aug 25. PMID: 32700464.
4: Guan Q, Li N, Shi L, Yu C, Gao X, Yang J, Guo Y, Li P, Zhu X. Aggregation- Induced Emission Fluorophore-Based Molecular Beacon for Differentiating Tumor and Normal Cells by Detecting the Specific and False-Positive Signals. ACS Biomater Sci Eng. 2019 Jul 8;5(7):3618-3630. doi: 10.1021/acsbiomaterials.9b00627. Epub 2019 Jun 4. PMID: 33405743.
5: Tarandovskiy ID, Rajabi AA, Karnaukhova E, Buehler PW. Contradictory to its effects on thrombin, C1-inhibitor reduces plasmin generation in the presence of thrombomodulin. J Thromb Thrombolysis. 2019 Jul;48(1):81-87. doi: 10.1007/s11239-019-01869-y. PMID: 31030323.
6: Santos-de-Souza R, Monteiro de Castro Côrtes L, Dos Santos Charret K, Cysne- Finkelstein L, Alves CR, Souza-Silva F. Serine Proteinases in Leishmania (Viannia) braziliensis Promastigotes Have Distinct Subcellular Distributions and Expression. Int J Mol Sci. 2019 Mar 15;20(6):1315. doi: 10.3390/ijms20061315. PMID: 30875904; PMCID: PMC6471289.
7: Molina-Bolívar JA, Galisteo-González F, Ruiz CC, Medina-O'Donnell M, Martínez A, Parra A. Maslinic acid conjugate with 7-amino-4-methylcoumarin as probe to monitor the temperature dependent conformational changes of human serum albumin by FRET. Spectrochim Acta A Mol Biomol Spectrosc. 2019 May 5;214:161-169. doi: 10.1016/j.saa.2019.02.014. Epub 2019 Feb 11. PMID: 30776717.
