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MedKoo Cat#: 592946 | Name: Aripiprazole cavoxil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aripiprazole cavoxil is used in Treatment of Schizophrenia, Bipolar Disorder, and Clinical Depression.

Chemical Structure

Aripiprazole cavoxil
Aripiprazole cavoxil
CAS#1259305-26-4 (cavoxil)

Theoretical Analysis

MedKoo Cat#: 592946

Name: Aripiprazole cavoxil

CAS#: 1259305-26-4 (cavoxil)

Chemical Formula: C30H39Cl2N3O4

Exact Mass: 575.2318

Molecular Weight: 576.56

Elemental Analysis: C, 62.50; H, 6.82; Cl, 12.30; N, 7.29; O, 11.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
129722-12-9 (free base) 851220-85-4 (hydrate) 1259305-26-4 (cavoxil) 1259305-29-7 (lauroxil)
Synonym
Aripiprazole cavoxil
IUPAC/Chemical Name
(7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl hexanoate
InChi Key
STDYTJDGBXCCRG-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H39Cl2N3O4/c1-2-3-4-10-29(37)39-22-35-27-21-24(13-11-23(27)12-14-28(35)36)38-20-6-5-15-33-16-18-34(19-17-33)26-9-7-8-25(31)30(26)32/h7-9,11,13,21H,2-6,10,12,14-20,22H2,1H3
SMILES Code
CCCCCC(OCN1C(CCC2=C1C=C(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)C=C2)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 576.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PLoS One. 2018 Aug 2;13(8):e0201371. doi: 10.1371/journal.pone.0201371. eCollection 2018. PubMed PMID: 30071042. 4: Takahashi K, Nakagawasai O, Nemoto W, Odaira T, Sakuma W, Tan-No K. Antidepressant-like effect of aripiprazole via 5-HT(1A), D(1), and D(2) receptors in the prefrontal cortex of olfactory bulbectomized mice. J Pharmacol Sci. 2018 Jul 7. pii: S1347-8613(18)30108-7. doi: 10.1016/j.jphs.2018.06.006. [Epub ahead of print] PubMed PMID: 30061071. 5: Pichler EM, Kawohl W, Seifritz E, Roser P. Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report. Int J Psychiatry Med. 2018 Jul 30:91217418791455. doi: 10.1177/0091217418791455. [Epub ahead of print] PubMed PMID: 30058466. 6: Jamróz W, Kurek M, Czech A, Szafraniec J, Gawlak K, Jachowicz R. 3D printing of tablets containing amorphous aripiprazole by filaments co-extrusion. Eur J Pharm Biopharm. 2018 Jul 23. pii: S0939-6411(18)30353-9. doi: 10.1016/j.ejpb.2018.07.017. [Epub ahead of print] PubMed PMID: 30048746. 7: Schneider-Thoma J, Efthimiou O, Huhn M, Krause M, Reichelt L, Röder H, Davis JM, Salanti G, Leucht S. Second-generation antipsychotic drugs and short-term mortality: a systematic review and meta-analysis of placebo-controlled randomised controlled trials. Lancet Psychiatry. 2018 Aug;5(8):653-663. doi: 10.1016/S2215-0366(18)30177-9. Epub 2018 Jul 2. PubMed PMID: 30042077. 8: López-Muñoz F, Shen WW, D'Ocon P, Romero A, Álamo C. A History of the Pharmacological Treatment of Bipolar Disorder. Int J Mol Sci. 2018 Jul 23;19(7). pii: E2143. doi: 10.3390/ijms19072143. Review. PubMed PMID: 30041458. 9: Ehret MJ, Davis E, Luttrell SE, Clark C. Aripiprazole Lauroxil NanoCrystal(®) Dispersion Technology (Aristada Initio(®)). Clin Schizophr Relat Psychoses. 2018 Summer;12(2):92-96. doi: 10.3371/CSRP.EHDA071918. PubMed PMID: 30040476. 10: Sepede G, Lorusso M, Spano MC, Di Nanno P, Di Iorio G, Di Giannantonio M. Efficacy and Safety of Atypical Antipsychotics in Bipolar Disorder With Comorbid Substance Dependence: A Systematic Review. Clin Neuropharmacol. 2018 Jul 21. doi: 10.1097/WNF.0000000000000297. [Epub ahead of print] PubMed PMID: 30036197. 11: D'Urso G, Anastasia A, Toscano E, Patti S, de Bartolomeis A. Aripiprazole-induced atrial fibrillation in a patient with concomitant risk factors. Exp Clin Psychopharmacol. 2018 Jul 23. doi: 10.1037/pha0000219. [Epub ahead of print] PubMed PMID: 30035575. 12: Balon R. The inexplicable rise of medication prices. Ann Clin Psychiatry. 2018 Aug;30(3):165-166. PubMed PMID: 30028889. 13: Navarro-Triviño FJ, de Jaime Ruiz P, Porras Segovia A, Garrido Torres-Puchol V. Oral Isotretinoin for the treatment of Aripiprazol-induced acneiform rash. Dermatol Ther. 2018 Jul 17:e12637. doi: 10.1111/dth.12637. [Epub ahead of print] PubMed PMID: 30019366. 14: Hattori S, Suda A, Kishida I, Miyauchi M, Shiraishi Y, Fujibayashi M, Tsujita N, Ishii C, Ishii N, Moritani T, Taguri M, Hirayasu Y. Effects of ABCB1 gene polymorphisms on autonomic nervous system activity during atypical antipsychotic treatment in schizophrenia. BMC Psychiatry. 2018 Jul 17;18(1):231. doi: 10.1186/s12888-018-1817-5. PubMed PMID: 30016952; PubMed Central PMCID: PMC6050702. 15: Tajiri M, Suzuki Y, Sugai T, Tsuneyama N, Someya T. Effects of olanzapine on resting heart rate in Japanese patients with schizophrenia. PLoS One. 2018 Jul 17;13(7):e0199922. doi: 10.1371/journal.pone.0199922. eCollection 2018. PubMed PMID: 30016331; PubMed Central PMCID: PMC6049914. 16: Hard ML, Wehr AY, Du Y, Weiden PJ, Walling D, von Moltke L. Pharmacokinetic Evaluation of a 1-Day Treatment Initiation Option for Starting Long-Acting Aripiprazole Lauroxil for Schizophrenia. J Clin Psychopharmacol. 2018 Jul 13. doi: 10.1097/JCP.0000000000000921. [Epub ahead of print] PubMed PMID: 30015676. 17: Stefatos A, Ha JN, Baranchuk A, Baldessarini RJ, Vázquez GH. Atrial Fibrillation and Injected Aripiprazole: A Case Report. Innov Clin Neurosci. 2018 Jun 1;15(5-6):43-45. PubMed PMID: 30013819; PubMed Central PMCID: PMC6040719. 18: Channing J, Mitchell M, Cortese S. Lurasidone in Children and Adolescents: Systematic Review and Case Report. J Child Adolesc Psychopharmacol. 2018 Jul 13. doi: 10.1089/cap.2018.0046. [Epub ahead of print] PubMed PMID: 30004236. 19: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501016/ PubMed PMID: 30000075. 20: Predictive factors of overall functioning improvement in patients with chronic schizophrenia and schizoaffective disorder treated with paliperidone palmitate and aripiprazole monohydrate. Hum Psychopharmacol. 2018 Jul;33(4):e2666. doi: 10.1002/hup.2666. PubMed PMID: 29992643.