Talmapimod, also known as SD-282, is an ATP-competitive inhibitor of p38 kinase. SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation. SD-282 may have potential therapeutic value of p38alpha MAPK inhibitors in the treatment of aberrant pain sensitivity produced by diabetes.
MedKoo Cat#: 510244
Name: Talmapimod
CAS#: 309913-83-5 (free base)
Chemical Formula: C27H30ClFN4O3
Exact Mass: 512.1991
Molecular Weight: 513.00
Elemental Analysis: C, 63.21; H, 5.89; Cl, 6.91; F, 3.70; N, 10.92; O, 9.36
The following data is based on the product molecular weight 513.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
