CI-936 is a purine receptor agonist that has been evaluated for its potential as an antipsychotic agent. In preclinical studies, CI-936 demonstrated antipsychotic-like activity in mice by inhibiting motor activity without producing significant ataxia. It also selectively blocked responses in the Sidman avoidance paradigm, a test predictive of antipsychotic activity. However, the lack of selectivity of CI-936 for its central nervous system versus cardiovascular actions and other side effects precluded further development.
MedKoo Cat#: 145841
Name: CI-936
CAS#: 98383-40-5
Chemical Formula: C24H25N5O4
Exact Mass: 447.1900
Molecular Weight: 447.50
Elemental Analysis: C, 64.42; H, 5.63; N, 15.65; O, 14.30
The following data is based on the product molecular weight 447.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
