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MedKoo Cat#: 592788 | Name: Tubocurarine chloride pentahydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tubocurarine chloride pentahydrate is a neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.

Chemical Structure

Tubocurarine chloride pentahydrate
Tubocurarine chloride pentahydrate
CAS#6989-98-6 (chloride pentahydrate)

Theoretical Analysis

MedKoo Cat#: 592788

Name: Tubocurarine chloride pentahydrate

CAS#: 6989-98-6 (chloride pentahydrate)

Chemical Formula: C37H52Cl2N2O11

Exact Mass: 0.0000

Molecular Weight: 771.73

Elemental Analysis: C, 57.59; H, 6.79; Cl, 9.19; N, 3.63; O, 22.80

Price and Availability

Size Price Availability Quantity
250mg USD 350.00 2 Weeks
1g USD 950.00 2 Weeks
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Related CAS #
57-94-3 (chloride) 57-94-4 (free base) 6989-98-6 (chloride pentahydrate)
Synonym
Tubocurarine chloride pentahydrate
IUPAC/Chemical Name
(11S,51R)-36,57-dihydroxy-16,56-dimethoxy-12,52,52-trimethyl-11,12,13,14,51,52,53,54-octahydro-2,6-dioxa-1(7,1),5(1,8)-diisoquinolina-3(1,3),7(1,4)-dibenzenacyclooctaphan-52-ium chloride hydrochloride pentahydrate
InChi Key
WMIZITXEJNQAQK-GGDSLZADSA-N
InChi Code
InChI=1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1
SMILES Code
COC1=C(O)C(OC2=CC=C(C[C@]3([H])N(C)CCC4=C3C=C5C(OC)=C4)C=C2)=C([C@](CC6=CC(O5)=C(O)C=C6)([H])[N+](C)(C)CC7)C7=C1.[H]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Cl-]
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 771.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Poulsen H, Hougs W. The effect of some curarizing drugs in unanaesthetized man. I. d-Tubocurarine chloride, gallamonium iodide, decamethonium iodide, succinylcholine iodide and its bis-monoethyl-substituted derivative in single or repeated doses. Acta Anaesth. Scandinav. 1957, 1, 15-39. Acta Anaesthesiol Scand. 2007 Sep;51(8):1018-42; discussion 1043. PubMed PMID: 17697296. 2: Annan RS, Kim C, Martyn J. Measurement of D-tubocurarine chloride in human urine using solid-phase extraction and reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 1990 Mar 16;526(1):228-34. PubMed PMID: 2341537. 3: Donnelly AJ, Golembiewski JA, Skupski R, Wojtynek JE. Criteria for use of pancuronium bromide, vecuronium bromide, atracurium besylate, tubocurarine chloride, metocurine iodide, pipecuronium bromide, and doxacurium chloride in adults. Clin Pharm. 1992 May;11(5):435-41. PubMed PMID: 1349856. 4: Wu J, Xie FS. Dimethyl-1-curine dimethochloride--an alternative for d-tubocurarine chloride. Chin Med J (Engl). 1987 Mar;100(3):173-6. PubMed PMID: 2957178.