JTE-013-9d is a S1PR2 antagonist (KD = 34.8 nM) derived from JTE-013 and has been shown to successfully inhibit the expression of dihydropyrimidine dehydrogenase (DPD). A potential application of the analog is for the reversal of 5-FU resistance for the treatment of colorectal cancer. Furthermore, JTE-013-9d resulted in a decrease in DPD expression in tumor and liver tissues as demonstrated through western blotting analysis and immunohistochemistry.
MedKoo Cat#: 130136
Name: JTE-013-9d
CAS#: N/A
Chemical Formula: C19H14Cl2FN7O
Exact Mass: 445.0621
Molecular Weight: 446.27
Elemental Analysis: C, 51.14; H, 3.16; Cl, 15.89; F, 4.26; N, 21.97; O, 3.59
The following data is based on the product molecular weight 446.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
