Synonym
Oxeladin; EC 207-412-1; Oxeladina; Oxeladine; Oxeladinum
IUPAC/Chemical Name
2-(2-Diethylaminoethoxy)ethyl 2-ethyl-2-phenylbutyrate
InChi Key
IQADUMSPOQKAAO-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H33NO3/c1-5-20(6-2,18-12-10-9-11-13-18)19(22)24-17-16-23-15-14-21(7-3)8-4/h9-13H,5-8,14-17H2,1-4H3
SMILES Code
CCC(C1=CC=CC=C1)(CC)C(OCCOCCN(CC)CC)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
335.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lartigue-Mattei C, Galmier MJ, Chabard JL, Beyssac E, Aiache JM. Determination of oxeladin in human plasma by gas chromatography--mass spectrometry. Biomed Chromatogr. 1995 Jan-Feb;9(1):32-5. PubMed PMID: 7734931.
2: DAVID A, LEITH-ROSS F, VALLANCE DK. Antitussive and other pharmacological properties of the diethylaminoethoxyethyl ester of alpha alpha-diethylphenylacetic acid, (oxeladin). J Pharm Pharmacol. 1957 Jul;9(7):446-58. PubMed PMID: 13439531.
3: El-Gindy A. High performance liquid chromatographic determination of oxeladin citrate and oxybutynin hydrochloride and their degradation products. Farmaco. 2005 Aug;60(8):689-99. PubMed PMID: 16023117.
4: Takagi K, Yuizono T, Kasé Y. [On the site of antitussive action of 2-(2-diethylaminoethoxy)ethyl alpha,alpha-diethylphenylacetate (Oxeladin)]. Yakugaku Zasshi. 1967 Aug;87(8):898-906. Japanese. PubMed PMID: 5625837.
5: Salvesen B, Haugland T. Determination of oxeladin in human sera by gas--liquid chromatography with thermionic detection. J Chromatogr. 1981 Oct 9;225(2):463-8. PubMed PMID: 7298782.
6: OZAWA H, FUKUDA H, OTSUKI I, CHIBA S. [Antitussive activity and acute toxicity of 2-(2-diethylamino-ethoxy)ethyl alpha,alpha-diethylphenylacetate (oxeladin)]. Yakugaku Zasshi. 1962 Sep;82:1314-7. Japanese. PubMed PMID: 13940888.
7: Knopp C, Korsatko W. [Determination of oxeladin citrate in drug combinations]. Pharmazie. 1982 Jan;37(1):76-7. German. PubMed PMID: 7071116.
8: Tarayre JP, Vilain P, Lauressergues H, Cauquil J, Bru M, Caillol V, Pouget G, Jougla AM, Go M. Pharmacological study of the antitussive and respiratory-analeptic properties of N-(2'-ethylpyrrolidino)diphenylacetamide hydrochloride (F 1459). Arzneimittelforschung. 1983;33(7):931-5. PubMed PMID: 6684929.
