NSC81111 displayed stronger antiproliferative activities than erlotinib with IC50 values between 0.95 and 17.71 μM against overexpressed EGFR-TK cancer cell lines: A431 and HeLa. Furthermore, calculations of the physicochemical properties suggest the compounds are drug-like and are potentially active orally.
MedKoo Cat#: 208190
Name: NSC81111
CAS#: 1678-14-4
Chemical Formula: C19H16O4
Exact Mass: 308.1049
Molecular Weight: 308.33
Elemental Analysis: C, 74.01; H, 5.23; O, 20.76
The following data is based on the product molecular weight 308.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
