MedKoo Cat#: 130137 | Name: OF1105

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OF1105 is a novel TRPA1 antagonist with potential use as a treatment for osteosarcomas. OF1105 has been found to lead to a reduction in human osteosarcoma MG-63 cell viability, motility, and the expression of IL-6 and TNF-α.

Chemical Structure

OF1105
OF1105
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130137

Name: OF1105

CAS#: N/A

Chemical Formula: C16H19NO4S3

Exact Mass: 385.0476

Molecular Weight: 385.51

Elemental Analysis: C, 49.85; H, 4.97; N, 3.63; O, 16.60; S, 24.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
OF1105
IUPAC/Chemical Name
N-(2,2-dioxidobenzo[e][1,2]oxathiin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide
InChi Key
UYLFHIVJEVNVSM-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19NO4S3/c18-16(4-2-1-3-14-7-9-22-23-14)17-13-5-6-15-12(11-13)8-10-24(19,20)21-15/h5-6,8,10-11,14H,1-4,7,9H2,(H,17,18)
SMILES Code
O=C(NC1=CC=C(OS(C=C2)(=O)=O)C2=C1)CCCCC3SSCC3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 385.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Francesconi O, Corzana F, Kontogianni GI, Pesciullesi G, Gualdani R, Supuran CT, Angeli A, Kavasi RM, Chatzinikolaidou M, Nativi C. Lipoyl-Based Antagonists of Transient Receptor Potential Cation A (TRPA1) Downregulate Osteosarcoma Cell Migration and Expression of Pro-Inflammatory Cytokines. ACS Pharmacol Transl Sci. 2022 Sep 13;5(11):1119-1127. doi: 10.1021/acsptsci.2c00114. PMID: 36407953; PMCID: PMC9667541.