WIN 66306 | CAS#151928-32-4 | NK1 & NK2 receptor antagonist

MedKoo Cat#: 464002 | Name: WIN 66306

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.

Chemical Structure

WIN 66306

CAS#151928-32-4

Theoretical Analysis

MedKoo Cat#: 464002

Name: WIN 66306

CAS#: 151928-32-4

Chemical Formula: C41H52N8O9

Exact Mass: 800.3857

Molecular Weight: 800.91

Elemental Analysis: C, 61.49; H, 6.54; N, 13.99; O, 17.98

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 550.00	2 Weeks
5mg	USD 1,350.00	2 Weeks

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Related CAS #

No Data

Synonym

WIN 66306; WIN66306; WIN-66306;

IUPAC/Chemical Name

(6S,12S,18S,23aS)-18-((1H-indol-3-yl)methyl)-12-((R)-hydroxy(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)methyl)-6-isopropylhexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13,16,19]heptaazacyclohenicosine-1,4,7,10,13,16,19-heptaone

InChi Key

BNPYZZVTLFIGQT-FAWZPQLUSA-N

InChi Code

InChI=1S/C41H52N8O9/c1-22(2)11-12-24-16-25(13-14-31(24)50)37(54)36-40(57)45-19-32(51)46-29(17-26-18-42-28-9-6-5-8-27(26)28)41(58)49-15-7-10-30(49)38(55)43-20-33(52)47-35(23(3)4)39(56)44-21-34(53)48-36/h5-6,8-9,11,13-14,16,18,23,29-30,35-37,42,50,54H,7,10,12,15,17,19-21H2,1-4H3,(H,43,55)(H,44,56)(H,45,57)(H,46,51)(H,47,52)(H,48,53)/t29-,30-,35-,36-,37+/m0/s1

SMILES Code

O=C1N2[C@@]([H])(CCC2)C(NCC(N[C@@H](C(C)C)C(NCC(N[C@@]([H])([C@H](O)C3=CC(C/C=C(C)\C)=C(O)C=C3)C(NCC(N[C@H]1CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 800.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Barrow CJ, Sedlock DM, Sun HH, Cooper R, Gillum AM. WIN 66306, a new neurokinin antagonist produced by an Aspergillus species: fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo). 1994 Nov;47(11):1182-7. doi: 10.7164/antibiotics.47.1182. PMID: 7528191.