Synonym
Rwj 22108; Rwj-22108; Rwj22108;
IUPAC/Chemical Name
2-(benzyl(methyl)amino)ethyl 4-(2-chloro-6-fluorophenyl)-2-methyl-1,4,6,7,8,9-hexahydrothiepino[3,2-b]pyridine-3-carboxylate 5,5-dioxide
InChi Key
AHYGPFWAZFOLSI-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H30ClFN2O4S/c1-18-23(27(32)35-15-14-31(2)17-19-9-4-3-5-10-19)25(24-20(28)11-8-12-21(24)29)26-22(30-18)13-6-7-16-36(26,33)34/h3-5,8-12,25,30H,6-7,13-17H2,1-2H3
SMILES Code
O=C(C1=C(C)NC(CCCC2)=C(S2(=O)=O)C1C3=C(F)C=CC=C3Cl)OCCN(C)CC4=CC=CC=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
533.05
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dodd JH, Schwender CF, Moore JB Jr, Ritchie DM, Gray-Nunez Y, Loughney D, Kirchner T, Miller WC, Mockoviak S. Design and discovery of RWJ 22108--a novel bronchoselective calcium channel blocker. Drug Des Discov. 1998 May;15(3):135-48. PubMed PMID: 9689497.
2: Moore JB Jr, Miller WC, Mockoviak S. RWJ-22108--a novel airway tissue--selective calcium channel blocker. Agents Actions. 1993 Sep;40(1-2):57-61. PubMed PMID: 8147270.
3: Ritchie DM, Kirchner T, Moore JB, Dodd JH, Ahmed T, Anderson DW, Capetola RJ. Experimental antiasthmatic activity of RWJ 22108: a bronchoselective calcium entry blocker. Int Arch Allergy Immunol. 1993;100(3):274-82. PubMed PMID: 8453315.
4: Dodd JH, Schwender CF, Conley RA, Moore JB Jr, Ritchie DM, Fabian AC, Fenk CJ, Bourcet E, Gray-Nunez Y, Kirchner T, et al. Synthesis and biological properties of RWJ 22108, a bronchoselective calcium channel blocker. Drug Des Discov. 1993;10(1):65-75. PubMed PMID: 8399994.
5: Yamakage M, Hirshman CA, Namiki A, Croxton TL. Inhibition of voltage-dependent Ca2+ channels of porcine tracheal smooth muscle by the novel Ca2+ channel antagonist RWJ-22108. Gen Pharmacol. 1997 May;28(5):689-94. PubMed PMID: 9184803.
