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MedKoo Cat#: 532997 | Name: ZD7288
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZD7288 is a sino-atrial node function modulator. It blocks the hyperpolarization activated cation current If (HCN channel). ZD7288 blocks Ih in central neurons and increases NMDA-evoked noradrenalin release in rat brain in vitro.

Chemical Structure

ZD7288
ZD7288
CAS#133059-99-1

Theoretical Analysis

MedKoo Cat#: 532997

Name: ZD7288

CAS#: 133059-99-1

Chemical Formula: C15H20N4

Exact Mass: 256.1688

Molecular Weight: 256.35

Elemental Analysis: C, 70.28; H, 7.86; N, 21.86

Price and Availability

Size Price Availability Quantity
5mg USD 275.00 2 Weeks
10mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
ZD7288; ZD-7288; ZD 7288.
IUPAC/Chemical Name
N-ethyl-1,2-dimethyl-6-methylimino-N-phenylpyrimidin-4-amine
InChi Key
JABSKGQQWUDVRU-PEZBUJJGSA-N
InChi Code
InChI=1S/C15H20N4/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15/h6-11H,5H2,1-4H3/b16-14-
SMILES Code
C/N=C1C=C(N(CC)C2=CC=CC=C2)N=C(C)N/1C
Appearance
White to off-white solid powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 256.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ziyatdinova NI, Kuptsova AM, Faskhutdinov LI, Shakirov RR, Zefirov TL. The Effect of α2-Adrenergic Receptor Stimulation on the Isolated Hearts from Rats with Acute Myocardial Infarction against the Background of If Blockade. Bull Exp Biol Med. 2025 Feb 13. doi: 10.1007/s10517-025-06324-y. Epub ahead of print. PMID: 39948175. 2: Amakhin DV, Sinyak DS, Soboleva EB, Zaitsev AV. HCN channels promote Na/K-ATPase activity during slow afterhyperpolarization after seizure-like events in vitro. J Physiol. 2025 Feb 7. doi: 10.1113/JP286965. Epub ahead of print. PMID: 39918972. 3: Trojan M, Kanigowski D, Bijoch Ł, Pękała M, Legutko D, Beroun A, Bekisz M, Colom LV, Kodirov SA. Deciphering the peculiarities of cell types in the septum. Neuroscience. 2025 Jan 26;565:327-341. doi: 10.1016/j.neuroscience.2024.11.063. Epub 2024 Nov 26. PMID: 39603403; PMCID: PMC11700767. 4: Li C, Lu T, Pan C, Hu C. Glucocorticoids Selectively Inhibit Hippocampal CA1 Pyramidal Neurons Activity Through HCN Channels. Int J Mol Sci. 2024 Nov 7;25(22):11971. doi: 10.3390/ijms252211971. PMID: 39596039; PMCID: PMC11593447. 5: Choi K, Yi JH, Park K, Woo C, Lee C, Kang SJ, Shin KS. HCN channel-dependent presynaptic potentiation at LA-BA synapses is required for fear memory formation. Biochem Biophys Res Commun. 2024 Nov 19;734:150788. doi: 10.1016/j.bbrc.2024.150788. Epub 2024 Oct 2. PMID: 39368374. 6: Gong LN, Liu HW, Lai K, Zhang Z, Mao LF, Liu ZQ, Li MX, Yin XL, Liang M, Shi HB, Wang LY, Yin SK. Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain. J Neurosci. 2024 Nov 6;44(45):e0442242024. doi: 10.1523/JNEUROSCI.0442-24.2024. PMID: 39313321; PMCID: PMC11551895. 7: Yin J, Li Y, Li D, Chang C, Weng X. Upregulation of HCN2 in ventral tegmental area is involved in morphine-induced conditioned place preference in rats. FEBS Open Bio. 2024 Dec;14(12):1996-2005. doi: 10.1002/2211-5463.13888. Epub 2024 Sep 12. PMID: 39267158; PMCID: PMC11609580. 8: Lai HJ, Kuo YC, Ting CH, Yang CC, Kao CH, Tsai YC, Chao CC, Hsueh HW, Hsieh PF, Chang HY, Wang IF, Tsai LK. Increase of HCN current in SOD1-associated amyotrophic lateral sclerosis. Brain. 2024 Dec 3;147(12):4240-4253. doi: 10.1093/brain/awae248. PMID: 39088003. 9: Wei F, Chen T, Huang Y, Yang Y, Cheng X, Yang L. Multiple Exposures to Sevoflurane General Anesthesia During Pregnancy Inhibit CaMKII/CREB Axis by Downregulating HCN2 to Induce an Autism-Like Phenotype in Offspring Mice. J Mol Neurosci. 2024 Jul 17;74(3):69. doi: 10.1007/s12031-024-02243-1. PMID: 39017898. 10: Ren L, Yu J, Chen H, Luo J, Lv F, Min S. Alteration of hyperpolarization- activated cation current-mediated metaplasticity contributes to electroconvulsive shock-induced learning and memory impairment in depressed rats. Front Psychiatry. 2024 Jun 7;15:1365119. doi: 10.3389/fpsyt.2024.1365119. PMID: 38911706; PMCID: PMC11190359. 11: Sun Y, Darmani NA. A Comparative Study of the Antiemetic Effects of α2-Adrenergic Receptor Agonists Clonidine and Dexmedetomidine against Diverse Emetogens in the Least Shrew (Cryptotis parva) Model of Emesis. Int J Mol Sci. 2024 Apr 23;25(9):4603. doi: 10.3390/ijms25094603. PMID: 38731821; PMCID: PMC11083949. 12: Zhang T, Liao X, Chen Y, Shu X, Liu D, Yao Y. Dexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current. Drug Des Devel Ther. 2024 Apr 9;18:1103-1114. doi: 10.2147/DDDT.S450971. PMID: 38618283; PMCID: PMC11015855. 13: Doldur-Balli F, Smieszek SP, Keenan BT, Zimmerman AJ, Veatch OJ, Polymeropoulos CM, Birznieks G, Polymeropoulos MH. Screening effects of HCN channel blockers on sleep/wake behavior in zebrafish. Front Neurosci. 2024 Mar 19;18:1375484. doi: 10.3389/fnins.2024.1375484. PMID: 38567282; PMCID: PMC10986788. 14: Pang JJ, Jiang X, Wu SM. Linear and Nonlinear Behaviors of the Photoreceptor Coupled Network. J Neurosci. 2024 Apr 17;44(16):e1433232024. doi: 10.1523/JNEUROSCI.1433-23.2024. PMID: 38423760; PMCID: PMC11026348. 15: Wang X, Wang Q, Song M, Wang Y, Shen X, Sun Y, Guo C, Geng P, Ma C, Jin X. Chronic but not acute nicotine treatment ameliorates acute inflammation-induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice. CNS Neurosci Ther. 2024 Feb;30(2):e14627. doi: 10.1111/cns.14627. PMID: 38353058; PMCID: PMC10865150. 16: Li Z, Shu Q, Chen Q, Yang H, Liu L, He Z, Lin H, Li Z. HCN1 in the lateral habenula contributes to morphine abstinence-induced anxiety-like behaviors in male mice. J Psychiatr Res. 2024 Mar;171:185-196. doi: 10.1016/j.jpsychires.2024.01.037. Epub 2024 Jan 28. PMID: 38301534. 17: Ma Y, Chen J, Chen C, Wei B, Liu X. Suppression of HCN channels in the spinal dorsal horn restores KCC2 expression and attenuates diabetic neuropathic pain. Neurosci Lett. 2024 Feb 6;822:137626. doi: 10.1016/j.neulet.2024.137626. Epub 2024 Jan 6. PMID: 38191090. 18: Wu J, El-Hassar L, Datta D, Thomas M, Zhang Y, Jenkins DP, DeLuca NJ, Chatterjee M, Gribkoff VK, Arnsten AFT, Kaczmarek LK. Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits. Mol Neurobiol. 2024 Apr;61(4):2430-2445. doi: 10.1007/s12035-023-03719-8. Epub 2023 Oct 27. PMID: 37889366. 19: Li L, Liu Y, Hu W, Yang J, Ma S, Tian Z, Cao Z, Pan K, Jiang M, Liu X, Wu S, Luo C, Xie RG. Peripheral CCL2 induces inflammatory pain via regulation of Ih currents in small diameter DRG neurons. Front Mol Neurosci. 2023 Oct 4;16:1144614. doi: 10.3389/fnmol.2023.1144614. PMID: 37860084; PMCID: PMC10582564. 20: He Z, Liu J, Zeng XL, Fan JH, Wang K, Chen Y, Li ZC, Zhao B. Inhibition of hyperpolarization-activated cyclic nucleotide-gated cation channel attenuates cerebral ischemia reperfusion-induced impairment of learning and memory by regulating apoptotic pathway. Metab Brain Dis. 2023 Dec;38(8):2751-2763. doi: 10.1007/s11011-023-01306-3. Epub 2023 Oct 20. PMID: 37857792.

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