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MedKoo Cat#: 208543 | Name: Pyromellitic dianhydride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Anhydrides are widely used as cross-linking agents in epoxy resins and alkyd production, for example, as coatings and adhesives in plastic products. Sensitisation to several anhydrides is known to cause occupational asthma. There are indications that the lesser known pyromellitic dianhydride (PMDA) can cause irritative respiratory symptoms and possibly asthma. Recently, researches found crosslinking pyromellitic dianhydride (PMDA) with cyclodestrin polymers have been found to have anti-HIV-1 activity

Chemical Structure

Pyromellitic dianhydride
Pyromellitic dianhydride
CAS#89-32-7

Theoretical Analysis

MedKoo Cat#: 208543

Name: Pyromellitic dianhydride

CAS#: 89-32-7

Chemical Formula: C10H2O6

Exact Mass: 217.9851

Molecular Weight: 218.12

Elemental Analysis: C, 55.07; H, 0.92; O, 44.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pyromellitic dianhydride, Benzene-1,2,4,5-tetracarboxylic dianhydride, EINECS 201-898-9, HSDB 6950, NSC 4798,
IUPAC/Chemical Name
1,2,4,5-Benzenetetracarboxylic 1,2:4,5-dianhydride
InChi Key
ANSXAPJVJOKRDJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H2O6/c11-7-3-1-4-6(10(14)16-8(4)12)2-5(3)9(13)15-7/h1-2H
SMILES Code
O=C(O1)C2=CC(C3=O)=C(C(O3)=O)C=C2C1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 218.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Adeoye O, Bártolo I, Conceição J, da Silva AB, Duarte N, Francisco AP, Taveira N, Cabral-Marques H. Pyromellitic dianhydride crosslinked soluble cyclodextrin polymers: Synthesis, lopinavir release from sub-micron sized particles and anti-HIV-1 activity. Int J Pharm. 2020 Jun 15;583:119356. doi: 10.1016/j.ijpharm.2020.119356. Epub 2020 Apr 20. PMID: 32325245. 2: Madsen MT, Skadhauge LR, Nielsen AD, Baelum J, Sherson DL. Pyromellitic dianhydride (PMDA) may cause occupational asthma. Occup Environ Med. 2019 Mar;76(3):175-177. doi: 10.1136/oemed-2018-105295. Epub 2019 Jan 11. PMID: 30635433; PMCID: PMC6581108. 3: Rafati N, Zarrabi A, Caldera F, Trotta F, Ghias N. Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations. J Microencapsul. 2019 Dec;36(8):715-727. doi: 10.1080/02652048.2019.1669728. Epub 2019 Sep 27. PMID: 31530203. 4: Kozieł K, Łagiewka J, Girek B, Folentarska A, Girek T, Ciesielski W. Synthesis of New Amino-β-Cyclodextrin Polymer, Cross-Linked with Pyromellitic Dianhydride and Their Use for the Synthesis of Polymeric Cyclodextrin Based Nanoparticles. Polymers (Basel). 2021 Apr 19;13(8):1332. doi: 10.3390/polym13081332. PMID: 33921681; PMCID: PMC8073293. 5: Vermeulen D, Corbin N, Goetz KP, Jurchescu OD, Coropceanu V, McNeil LE. Electron-phonon coupling in anthracene-pyromellitic dianhydride. J Chem Phys. 2017 Jun 7;146(21):214705. doi: 10.1063/1.4984268. PMID: 28595390. 6: Li Y, Jiang Z, Dong G, Ho W. Construction and Activity of an All-Organic Heterojunction Photocatalyst Based on Melem and Pyromellitic Dianhydride. ChemSusChem. 2022 Jun 22;15(12):e202200875. doi: 10.1002/cssc.202200875. Epub 2022 Jun 2. PMID: 35655290. 7: Guo Y, Wang R, Yan C, Wang P, Rao L, Wang C. Developing boron nitride- pyromellitic dianhydride composite for removal of aromatic pollutants from wastewater via adsorption and photodegradation. Chemosphere. 2019 Aug;229:112-124. doi: 10.1016/j.chemosphere.2019.04.196. Epub 2019 May 2. PMID: 31078026. 8: Deng J, Liu Y, Liu S, Zeng G, Tan X, Huang B, Tang X, Wang S, Hua Q, Yan Z. Competitive adsorption of Pb(II), Cd(II) and Cu(II) onto chitosan-pyromellitic dianhydride modified biochar. J Colloid Interface Sci. 2017 Nov 15;506:355-364. doi: 10.1016/j.jcis.2017.07.069. Epub 2017 Jul 18. PMID: 28750237. 9: Li Y, Jiang Z, Dong G, Ho W. Construction and Activity of an All-Organic Heterojunction Photocatalyst Based on Melem and Pyromellitic Dianhydride. ChemSusChem. 2022 Jun 22;15(12):e202200477. doi: 10.1002/cssc.202200477. Epub 2022 Apr 29. PMID: 35485996. 10: Konieczny S, Fik CP, Averesch NJ, Tiller JC. Organosoluble enzyme conjugates with poly(2-oxazoline)s via pyromellitic acid dianhydride. J Biotechnol. 2012 Jun 15;159(3):195-203. doi: 10.1016/j.jbiotec.2012.01.016. Epub 2012 Jan 26. PMID: 22306109.

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