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MedKoo Cat#: 598764 | Name: Anisperimus TFA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Anisperimus, also known as LF 15-0195, is an analogue of 15-deoxyspergualin and an immunosuppressive agent. LF 15-0195 treatment protects against central nervous system autoimmunity by favoring the development of Foxp3-expressing regulatory CD4 T cells. LF 15-0195 generates synergistic tolerance by promoting formation of CD4+CD25+CTLA4+ T cells. Monotherapy with LF 15-0195 significantly prolongs renal allograft survival in monkeys.

Chemical Structure

Anisperimus TFA
Anisperimus TFA
CAS#170368-05-5 (TFA)

Theoretical Analysis

MedKoo Cat#: 598764

Name: Anisperimus TFA

CAS#: 170368-05-5 (TFA)

Chemical Formula: C24H42F9N7O9

Exact Mass: 401.3114

Molecular Weight: 743.63

Elemental Analysis: C, 38.76; H, 5.69; F, 22.99; N, 13.19; O, 19.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
170368-05-5 (TFA) 170368-04-4 (free base)
Synonym
Anisperimus; LF 15-0195; LF-15-0195; LF15-0195; LF 150195; LF-150195; LF150195;
IUPAC/Chemical Name
2-((6-guanidinohexyl)amino)-2-oxoethyl (R)-(4-((3-aminobutyl)amino)butyl)carbamate tris(2,2,2-trifluoroacetate)
InChi Key
LYMGSEOJOUVFSO-HKPSJHCMSA-N
InChi Code
InChI=1S/C18H39N7O3.3C2HF3O2/c1-15(19)8-13-22-9-6-7-12-25-18(27)28-14-16(26)23-10-4-2-3-5-11-24-17(20)21;3*3-2(4,5)1(6)7/h15,22H,2-14,19H2,1H3,(H,23,26)(H,25,27)(H4,20,21,24);3*(H,6,7)/t15-;;;/m1.../s1
SMILES Code
O=C(OCC(NCCCCCCNC(N)=N)=O)NCCCCNCC[C@H](N)C.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 743.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Le Berre L, Tilly G, Dantal J. Is there B cell involvement in a rat model of spontaneous idiopathic nephrotic syndrome treated with LF15-0195? J Nephrol. 2014 Jun;27(3):265-73. doi: 10.1007/s40620-014-0081-0. Epub 2014 Mar 25. PMID: 24664644. 2: Le Berre L, Bruneau S, Naulet J, Renaudin K, Buzelin F, Usal C, Smit H, Condamine T, Soulillou JP, Dantal J. Induction of T regulatory cells attenuates idiopathic nephrotic syndrome. J Am Soc Nephrol. 2009 Jan;20(1):57-67. doi: 10.1681/ASN.2007111244. Epub 2008 Nov 19. PMID: 19020006; PMCID: PMC2615726. 3: Zhang X, Li M, Lian D, Zheng X, Zhang ZX, Ichim TE, Xia X, Huang X, Vladau C, Suzuki M, Garcia B, Jevnikar AM, Min WP. Generation of therapeutic dendritic cells and regulatory T cells for preventing allogeneic cardiac graft rejection. Clin Immunol. 2008 Jun;127(3):313-21. doi: 10.1016/j.clim.2008.01.013. Epub 2008 Mar 20. PMID: 18358783. 4: Zhong T, Liu Y, Jiang J, Wang H, Temple CL, Sun H, Garcia B, Zhong R, Ross DC. Long-term limb allograft survival using a short course of anti-CD45RB monoclonal antibody, LF 15-0195, and rapamycin in a mouse model. Transplantation. 2007 Dec 27;84(12):1636-43. doi: 10.1097/01.tp.0000290277.23186.ad. PMID: 18165776. 5: Thebault P, Condamine T, Heslan M, Hill M, Bernard I, Saoudi A, Josien R, Anegon I, Cuturi MC, Chiffoleau E. Role of IFNgamma in allograft tolerance mediated by CD4+CD25+ regulatory T cells by induction of IDO in endothelial cells. Am J Transplant. 2007 Nov;7(11):2472-82. doi: 10.1111/j.1600-6143.2007.01960.x. Epub 2007 Sep 14. PMID: 17868070. 6: Heslan JM, Renaudin K, Thebault P, Josien R, Cuturi MC, Chiffoleau E. New evidence for a role of allograft accommodation in long-term tolerance. Transplantation. 2006 Nov 15;82(9):1185-93. doi: 10.1097/01.tp.0000236573.01428.f3. PMID: 17102770. 7: Popov I, Li M, Zheng X, San H, Zhang X, Ichim TE, Suzuki M, Feng B, Vladau C, Zhong R, Garcia B, Strejan G, Inman RD, Min WP. Preventing autoimmune arthritis using antigen-specific immature dendritic cells: a novel tolerogenic vaccine. Arthritis Res Ther. 2006;8(5):R141. doi: 10.1186/ar2031. PMID: 16911769; PMCID: PMC1779442. 8: Pêche H, Renaudin K, Beriou G, Merieau E, Amigorena S, Cuturi MC. Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC- mismatched rat cardiac allograft model. Am J Transplant. 2006 Jul;6(7):1541-50. doi: 10.1111/j.1600-6143.2006.01344.x. PMID: 16827854. 9: Duplan V, Beriou G, Heslan JM, Bruand C, Dutartre P, Mars LT, Liblau RS, Cuturi MC, Saoudi A. LF 15-0195 treatment protects against central nervous system autoimmunity by favoring the development of Foxp3-expressing regulatory CD4 T cells. J Immunol. 2006 Jan 15;176(2):839-47. doi: 10.4049/jimmunol.176.2.839. PMID: 16393967. 10: Heslan JM, Beriou G, Le Luduec JB, Guillonneau C, Anegon I, Soulillou JP, Cuturi MC, Chiffoleau E. Accumulation of T cells with potent regulatory properties and restricted Vbeta7-TCR rearrangements in tolerated allografts. Transplantation. 2005 Nov 27;80(10):1476-84. doi: 10.1097/01.tp.0000185198.07663.ba. PMID: 16340794. 11: Xia X, Zhang X, Huang X, Li M, Zhao L, Tian D, Zhong R, Min WP. LF 15-0195 generates synergistic tolerance by promoting formation of CD4+CD25+CTLA4+ T cells. J Immunother. 2005 Nov-Dec;28(6):560-3. doi: 10.1097/01.cji.0000175693.08608.a8. PMID: 16224273. 12: Bériou G, Pêche H, Guillonneau C, Merieau E, Cuturi MC. Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression. Transplantation. 2005 Apr 27;79(8):969-72. doi: 10.1097/01.tp.0000158277.50073.35. PMID: 15849552. 13: Puppi J, Guillonneau C, Pichard V, Bellodi-Privato M, Cuturi MC, Anegon I, Ferry N. Long term transgene expression by hepatocytes transduced with retroviral vectors requires induction of immune tolerance to the transgene. J Hepatol. 2004 Aug;41(2):222-8. doi: 10.1016/j.jhep.2004.04.015. PMID: 15288470. 14: Zhou D, O'Brien C, Shum J, Garcia B, Min W, Jevnikar AM, Dutartre P, Zhong R. LF 15-0195, a novel immunosuppressive agent prevents rejection and induces operational tolerance in a mouse cardiac allograft model. Transplantation. 2003 Aug 27;76(4):644-50. doi: 10.1097/01.TP.0000071202.91772.90. PMID: 12973102. 15: Yang J, Bernier SM, Ichim TE, Li M, Xia X, Zhou D, Huang X, Strejan GH, White DJ, Zhong R, Min WP. LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity. J Leukoc Biol. 2003 Sep;74(3):438-47. doi: 10.1189/jlb.1102582. PMID: 12949248. 16: Manez R. Current trends in transplantation and immunosuppressive treatment. Drug News Perspect. 2003 Jun;16(5):332-6. PMID: 12942165. 17: Wang H, Hosiawa KA, Garcia B, Shum JB, Dutartre P, Kelvin DJ, Zhong R. Treatment with a short course of LF 15-0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat-to-mouse cardiac transplantation model. Xenotransplantation. 2003 Jul;10(4):325-36. doi: 10.1034/j.1399-3089.2003.02038.x. PMID: 12795681. 18: Wang H, Hosiawa KA, Garcia B, Shum JB, Dutartre P, Kelvin DJ, Zhong R. Attenuation of acute xenograft rejection by short-term treatment with LF15-0195 and monoclonal antibody against CD45RB in a rat-to-mouse cardiac transplantation model. Transplantation. 2003 May 15;75(9):1475-81. doi: 10.1097/01.TP.0000057245.59998.95. PMID: 12792500. 19: Ducoroy P, de Fornel D, Dubrez-Daloz L, Solary E, Dutartre P. Longterm protection of mice against collagen-induced arthritis after short-term LF 15-0195 treatment: modulation of B and T lymphocyte activation. J Rheumatol. 2003 May;30(5):918-25. PMID: 12734883. 20: Yang H, Chen G, Kanai N, Shum J, Garcia B, Huang X, Min W, Luo Y, Dutartre P, Zhong R. Monotherapy with LF 15-0195, an analogue of 15-deoxyspergualin, significantly prolongs renal allograft survival in monkeys. Transplantation. 2003 Apr 27;75(8):1166-71. doi: 10.1097/01.TP.0000062841.89728.CF. PMID: 12717197.

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