MedKoo Cat#: 573162 | Name: Anipamil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Anipamil is a calcium channel blocker of the phenylalkylamine type. Anipamil is an analog of the more common drug verapamil, which is the most common type of phenylalkylamine style calcium channel blocker. Anipamil has been shown to be a more effective antiarrhythmic medication than verapamil because it does not cause hypertension as seen in verapamil. It is able to do this by bonding to the myocardium tighter then verapamil.

Chemical Structure

Anipamil
Anipamil
CAS#83200-10-6

Theoretical Analysis

MedKoo Cat#: 573162

Name: Anipamil

CAS#: 83200-10-6

Chemical Formula: C34H52N2O2

Exact Mass: 520.4029

Molecular Weight: 520.80

Elemental Analysis: C, 78.41; H, 10.06; N, 5.38; O, 6.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Anipamil
IUPAC/Chemical Name
2-(3-((m-Methoxyphenethyl)methylamino)propyl)-2-(m-methoxyphenyl)tetradecanenitrile
InChi Key
PHFDAOXXIZOUIX-UHFFFAOYSA-N
InChi Code
1S/C34H52N2O2/c1-5-6-7-8-9-10-11-12-13-14-23-34(29-35,31-19-16-21-33(28-31)38-4)24-17-25-36(2)26-22-30-18-15-20-32(27-30)37-3/h15-16,18-21,27-28H,5-14,17,22-26H2,1-4H3
SMILES Code
CCCCCCCCCCCCC(CCCN(C)CCc1cccc(c1)OC)(C#N)c2cccc(c2)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 520.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pugsley MK, Ries CR, Guppy LJ, Harvie CJ, Walker MJ. Effects of anipamil, a long acting analog of verapamil, in pigs subjected to myocardial ischemia. Life Sci. 1995;57(12):1219-31. PubMed PMID: 7674811. 2: Sørum C, Larsen CT, Rasmussen V, Hansen JF. Efficacy of anipamil, a phenylalkylamine calcium antagonist, in treatment of angina pectoris. J Cardiovasc Pharmacol. 1994 Nov;24(5):841-5. PubMed PMID: 7532763. 3: Larsen CT, Sørum C, Rasmussen V, Fischer Hansen J. Anipamil prevents ST depression in patients with stable angina pectoris. Cardiovasc Drugs Ther. 1993 Dec;7(6):915-21. PubMed PMID: 8011571. 4: Raddino R, Poli E, Pasini E, Ferrari R. Effects of the novel calcium channel blocker, anipamil, on the isolated rabbit heart. Comparison with verapamil and gallopamil. Naunyn Schmiedebergs Arch Pharmacol. 1992 Sep;346(3):339-44. PubMed PMID: 1383837. 5: Ferrari R, Boraso A, Cargnoni A, Pasini E, Raddino R, Albertini A. Effects of anipamil on myocardial sarcolemmal and mitochondrial calcium transport, comparison with verapamil and nifedipine. Eur J Pharmacol. 1990 Sep 18;189(2-3):149-61. PubMed PMID: 2147656. 6: Kirchengast M, Raschack M. Effects of anipamil on electrocardiogram, plasma creatine kinase, and reperfusion arrhythmias after coronary occlusion in closed-chest rats. J Cardiovasc Pharmacol. 1989;13 Suppl 4:S73-5. PubMed PMID: 2475696.