Synonym
Leucyltyrosine; L-Leucyl-L-tyrosine;
IUPAC/Chemical Name
L-leucyl-L-tyrosine
InChi Key
LHSGPCFBGJHPCY-STQMWFEESA-N
InChi Code
InChI=1S/C15H22N2O4/c1-9(2)7-12(16)14(19)17-13(15(20)21)8-10-3-5-11(18)6-4-10/h3-6,9,12-13,18H,7-8,16H2,1-2H3,(H,17,19)(H,20,21)/t12-,13-/m0/s1
SMILES Code
OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC([C@H](CC(C)C)N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
Leucyltyrosine is a peptide.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
294.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Domingues P, Fonseca C, Reis A, Domingues MR. Identification of isomeric spin adducts of Leu-Tyr and Tyr-Leu free radicals using liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2012 Jan;26(1):51-60. doi: 10.1002/bmc.1624. Epub 2011 Mar 23. PubMed PMID: 21432862.
2: Lameiras P, Boudesocque L, Mouloungui Z, Renault JH, Wieruszeski JM, Lippens G, Nuzillard JM. Glycerol and glycerol carbonate as ultraviscous solvents for mixture analysis by NMR. J Magn Reson. 2011 Sep;212(1):161-8. doi: 10.1016/j.jmr.2011.06.021. Epub 2011 Jul 1. PubMed PMID: 21802324.
3: Waters SP, Noble ER, Dalling MJ. Intracellular Localization of Peptide Hydrolases in Wheat (Triticum aestivum L.) Leaves. Plant Physiol. 1982 Mar;69(3):575-9. PubMed PMID: 16662252; PubMed Central PMCID: PMC426257.
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5: Szyk A, Maurizi MR. Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site. J Struct Biol. 2006 Oct;156(1):165-74. Epub 2006 Apr 21. PubMed PMID: 16682229.
6: Daniel H, Adibi SA. Selective effect of zinc on uphill transport of oligopeptides into kidney brush border membrane vesicles. FASEB J. 1995 Aug;9(11):1112-7. PubMed PMID: 7649411.
7: Waters SP, Peoples MB, Simpson RJ, Dalling MJ. Nitrogen redistribution during grain growth in wheat (Triticum aestivum L.) : I. Peptide hydrolase activity and protein breakdown in the flag leaf, glumes and stem. Planta. 1980 Oct;148(5):422-8. doi: 10.1007/BF00552654. PubMed PMID: 24310182.
8: MILLER GW, GILLIS BT, LI NC. The effects of optical configuration of peptides. II. The reaction of diastereomeric leucyltyrosines with cobaltous ion and molecular oxygen. J Biol Chem. 1960 Oct;235:2840-4. PubMed PMID: 13770770.
9: Bradford HN, Schmaier AH, Colman RW. Kinetics of inhibition of platelet calpain II by human kininogens. Biochem J. 1990 Aug 15;270(1):83-90. PubMed PMID: 2396995; PubMed Central PMCID: PMC1131681.
10: Krause JA, Baures PW, Eggleston DS. Molecular structures of L-Leu-L-Tyr, Gly-D,L-Met.p-toluenesulfonate and L-His-L-Leu. Acta Crystallogr B. 1993 Feb 1;49 ( Pt 1):123-30. PubMed PMID: 8442925.
11: Fonseca C, Domingues MR, Simões C, Amado F, Domingues P. Reactivity of Tyr-Leu and Leu-Tyr dipeptides: identification of oxidation products by liquid chromatography-tandem mass spectrometry. J Mass Spectrom. 2009 May;44(5):681-93. doi: 10.1002/jms.1543. PubMed PMID: 19125397.
12: Kapitannikov IuV, Iavashev LP, Ginodman LM, Antonov VK. [Mechanism of oxygen exchange in the amide group of substrates during their hydrolysis catalyzed by leucine aminopeptidase and pepsin]. Bioorg Khim. 1983 Feb;9(2):228-31. Russian. PubMed PMID: 6435638.
13: Tsetlin VI, Ivanov VT, Ovchinnikov IuA. [Conformational aspects of peptide interaction with proteolytic enzymes. Pepsin-catalyzed hydrolysis of cyclic peptides, containing leucyl-tyrosine fragments]. Biokhimiia. 1975 Jul-Aug;40(4):694-7. Russian. PubMed PMID: 1106781.
