Selenazofurin | CAS#83705-13-9 | antiviral

MedKoo Cat#: 526329 | Name: Selenazofurin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Selenazofurin is an antiviral compound used against influenza A and B viruses. Selenazofurin inhibits the cytopathic effect and yield of influenza A/NWS/33 virus, with 50% effective dose ranges of 0.7 to 1.4 micrograms/ml (virus rating [VR], 1.3 to 1.4).

Chemical Structure

Selenazofurin

CAS#83705-13-9

Theoretical Analysis

MedKoo Cat#: 526329

Name: Selenazofurin

CAS#: 83705-13-9

Chemical Formula: C9H12N2O5Se

Exact Mass: 307.9911

Molecular Weight: 307.16

Elemental Analysis: C, 35.19; H, 3.94; N, 9.12; O, 26.04; Se, 25.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Selenazofurin; BRN 4198668; CI-935; CI 935; CI935.

IUPAC/Chemical Name

2-beta-D-Ribofuranosyl-4-selenazolecarboxamide

InChi Key

InChi Code

SMILES Code

O=C(C1=C[Se]C([C@H]2[C@@H]([C@@H]([C@@H](CO)O2)O)O)=N1)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 307.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pogrebniak A, Hasmann M, Schemainda I, Pelka-Fleischer R, Nuessler V. Cytoprotective features of selenazofurin in hematopoietic cells. Int J Clin Pharmacol Ther. 2002 Aug;40(8):368-75. PubMed PMID: 12467305. 2: Franchetti P, Cappellacci L, Sheikha GA, Jayaram HN, Gurudutt VV, Sint T, Schneider BP, Jones WD, Goldstein BM, Perra G, De Montis A, Loi AG, La Colla P, Grifantini M. Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin. J Med Chem. 1997 May 23;40(11):1731-7. PubMed PMID: 9171883. 3: Gharehbaghi K, Sreenath A, Hao Z, Paull KD, Szekeres T, Cooney DA, Krohn K, Jayaram HN. Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin. Biochem Pharmacol. 1994 Oct 7;48(7):1413-9. PubMed PMID: 7945441. 4: Smee DF, Gilbert J, Leonhardt JA, Barnett BB, Huggins JH, Sidwell RW. Treatment of lethal Pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen. Antiviral Res. 1993 Jan;20(1):57-70. PubMed PMID: 8384433. 5: Parandoosh Z, Robins RK, Belei M, Rubalcava B. Tiazofurin and selenazofurin induce depression of cGMP and phosphatidylinositol pathway in L1210 leukemia cells. Biochem Biophys Res Commun. 1989 Oct 31;164(2):869-74. PubMed PMID: 2554903. 6: Sidwell RW, Huffman JH, Call EW, Alaghamandan H, Cook PD, Robins RK. Effect of selenazofurin on influenza A and B virus infections of mice. Antiviral Res. 1986 Oct;6(6):343-53. PubMed PMID: 3022644. 7: Wray SK, Smith RH, Gilbert BE, Knight V. Effects of selenazofurin and ribavirin and their 5'-triphosphates on replicative functions of influenza A and B viruses. Antimicrob Agents Chemother. 1986 Jan;29(1):67-72. PubMed PMID: 3729336; PubMed Central PMCID: PMC180366. 8: Lee HJ, Pawlak K, Nguyen BT, Robins RK, Sadée W. Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture. Cancer Res. 1985 Nov;45(11 Pt 1):5512-20. PubMed PMID: 2865005. 9: Sidwell RW, Huffman JH, Call EW, Alaghamandan H, Cook PD, Robins RK. Activity of selenazofurin against influenza A and B viruses in vitro. Antimicrob Agents Chemother. 1985 Sep;28(3):375-7. PubMed PMID: 4073860; PubMed Central PMCID: PMC180256. 10: Berger NA, Berger SJ, Catino DM, Petzold SJ, Robins RK. Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by the synthetic "C" nucleoside analogs, tiazofurin and selenazofurin. A new strategy for cancer chemotherapy. J Clin Invest. 1985 Feb;75(2):702-9. PubMed PMID: 3919063; PubMed Central PMCID: PMC423562. 11: Robins RK, Revankar GR, McKernan PA, Murray BK, Kirsi JJ, North JA. The importance of IMP dehydrogenase inhibition in the broad spectrum antiviral activity of ribavirin and selenazofurin. Adv Enzyme Regul. 1985;24:29-43. PubMed PMID: 2872781. 12: Gebeyehu G, Marquez VE, Van Cott A, Cooney DA, Kelley JA, Jayaram HN, Ahluwalia GS, Dion RL, Wilson YA, Johns DG. Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogues. Synthesis, structure, and interactions with IMP dehydrogenase. J Med Chem. 1985 Jan;28(1):99-105. PubMed PMID: 2856943. 13: Kirsi JJ, McKernan PA, Burns NJ 3rd, North JA, Murray BK, Robins RK. Broad-spectrum synergistic antiviral activity of selenazofurin and ribavirin. Antimicrob Agents Chemother. 1984 Oct;26(4):466-75. PubMed PMID: 6517540; PubMed Central PMCID: PMC179946. 14: Huggins JW, Robins RK, Canonico PG. Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses. Antimicrob Agents Chemother. 1984 Oct;26(4):476-80. PubMed PMID: 6151377; PubMed Central PMCID: PMC179947.