Mesendogen | CAS#864716-85-8 | TRPM6 inhibitor

MedKoo Cat#: 527663 | Name: Mesendogen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mesendogen is a novel inhibitor of TRPM6, promoting mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis.

Chemical Structure

Mesendogen

CAS#864716-85-8

Theoretical Analysis

MedKoo Cat#: 527663

Name: Mesendogen

CAS#: 864716-85-8

Chemical Formula: C18H16ClF3N2OS

Exact Mass: 400.0624

Molecular Weight: 400.84

Elemental Analysis: C, 53.94; H, 4.02; Cl, 8.84; F, 14.22; N, 6.99; O, 3.99; S, 8.00

Price and Availability

Size	Price	Availability
25mg	USD 350.00	2 Weeks
50mg	USD 550.00	2 Weeks
100mg	USD 950.00	2 Weeks
1g	USD 3,850.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Mesendogen

IUPAC/Chemical Name

N-({[2-Chloro-5-(trifluoromethyl) phenyl]amino}carbonothioyl)-4-isopropylbenzamide

InChi Key

VVFIVYCBLSSVEK-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H16ClF3N2OS/c1-10(2)11-3-5-12(6-4-11)16(25)24-17(26)23-15-9-13(18(20,21)22)7-8-14(15)19/h3-10H,1-2H3,(H2,23,24,25,26)

SMILES Code

O=C(NC(NC1=CC(C(F)(F)F)=CC=C1Cl)=S)C2=CC=C(C(C)C)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Mesendogen is a novel inhibitor of TRPM6.

In vitro activity:

This study reports a novel small molecule Mesendogen (MEG) which robustly induces nearly homogeneous (≥85%) mesoderm and definitive endoderm (DE) differentiations of human embryonic stem cells (hESCs) in combination with growth factors. A kinome screen followed by loss-of-function experiments identified TRPM6 as the biological target of MEG. This study demonstrated that MEG functions by inhibiting TRPM6/TRPM7 magnesium channel activity, as MEG reduced intracellular magnesium level, while TRPM6/TRPM7 channel modulation and magnesium-withdrawal phenocopied MEG at enhancing mesoderm and DE differentiations. Reference: Heliyon. 2015 Dec 1;1(4):e00046. https://pubmed.ncbi.nlm.nih.gov/26705539/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 400.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Geng Y, Feng B. Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis. Heliyon. 2015 Dec 1;1(4):e00046. doi: 10.1016/j.heliyon.2015.e00046. PMID: 26705539; PMCID: PMC4685751.

In vitro protocol:

In vivo protocol:

TBD

1: Geng Y, Feng B. Mesendogen, a novel inhibitor of TRPM6, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells through alteration of magnesium homeostasis. Heliyon. 2015 Dec 1;1(4):e00046. PubMed PMID: 26705539; PubMed Central PMCID: PMC4685751.