Taniborbactam HCl | CAS#2244235-49-0 | Beta-lactamase inhibitor

MedKoo Cat#: 572149 | Name: Taniborbactam HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Taniborbactam, also known as VNRX-5133, is an injectable broad-spectrum β-lactamase inhibitor combined with a marketed β-lactam antibiotic. It may treat complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI). VNRX-5133 is a novel β-lactamase inhibitor with potent and selective direct inhibitory activity against both serine- and metallo-β-lactamases.

Chemical Structure

Taniborbactam HCl

CAS#2244235-49-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 572149

Name: Taniborbactam HCl

CAS#: 2244235-49-0 (HCl)

Chemical Formula: C19H30BCl2N3O5

Exact Mass: 389.2122

Molecular Weight: 462.18

Elemental Analysis: C, 49.38; H, 6.54; B, 2.34; Cl, 15.34; N, 9.09; O, 17.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

2244235-49-0 (HCl) 1613267-49-4 (free base) 1613268-23-7

Synonym

Taniborbactam HCl; Taniborbactam dihydrochloride; VNRX-5133; VNRX5133; VNRX 5133; Taniborbactam;

IUPAC/Chemical Name

(3R)-3-(2-{trans-4-[(2-aminoethyl)amino]cyclohexyl}acetamido)-2-hydroxy-3,4-dihydro-2H-1,2-benzoxaborinine-8-carboxylic acid dihydrochloride

InChi Key

CKWIMFZHNCBHIX-DKZBTPFISA-N

InChi Code

InChI=1S/C19H28BN3O5.2ClH/c21-8-9-22-14-6-4-12(5-7-14)10-17(24)23-16-11-13-2-1-3-15(19(25)26)18(13)28-20(16)27;;/h1-3,12,14,16,22,27H,4-11,21H2,(H,23,24)(H,25,26);2*1H/t12-,14-,16-;;/m0../s1

SMILES Code

O=C(C1=C(OB(O)[C@@H](NC(C[C@H]2CC[C@H](NCCN)CC2)=O)C3)C3=CC=C1)O.[H]Cl.[H]Cl)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 462.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Drawz SM, Bonomo RA. Three decades of beta-lactamase inhibitors. Clin Microbiol Rev. 2010 Jan;23(1):160-201. doi: 10.1128/CMR.00037-09. Review. PubMed PMID: 20065329; PubMed Central PMCID: PMC2806661.