MedKoo Cat#: 463623 | Name: VISTA modulator 6809-0223

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VISTA modulator 6809-0223 is a novel immune checkpoint VISTA (V-domain immunoglobulin suppressor of T-cell activation) modulator.

Chemical Structure

VISTA modulator 6809-0223
VISTA modulator 6809-0223
CAS#669749-25-1

Theoretical Analysis

MedKoo Cat#: 463623

Name: VISTA modulator 6809-0223

CAS#: 669749-25-1

Chemical Formula: C18H17N7OS2

Exact Mass: 411.0936

Molecular Weight: 411.50

Elemental Analysis: C, 52.54; H, 4.16; N, 23.83; O, 3.89; S, 15.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
VISTA modulator 6809-0223; VISTA modulator 68090223; VISTA modulator 6809 0223;
IUPAC/Chemical Name
2-((4,6-dimethylquinazolin-2-yl)amino)-6-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)pyrimidin-4(3H)-one
InChi Key
YIJOQQHVEVIMNS-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17N7OS2/c1-9-4-5-14-13(6-9)10(2)19-16(21-14)23-17-20-12(7-15(26)22-17)8-27-18-25-24-11(3)28-18/h4-7H,8H2,1-3H3,(H2,19,20,21,22,23,26)
SMILES Code
O=C1NC(NC2=NC(C)=C3C=C(C)C=CC3=N2)=NC(CSC4=NN=C(C)S4)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 411.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zong L, Yu S, Mo S, Zhou Y, Xiang Y, Lu Z, Chen J. High VISTA Expression Correlates With a Favorable Prognosis in Patients With Colorectal Cancer. J Immunother. 2021 Jan;44(1):22-28. doi: 10.1097/CJI.0000000000000343. PMID: 33086339.